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Tbio
GJA8
Gap junction alpha-8 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369235
  • ENSP00000358238
  • ENSG00000121634

Symbol
  • CAE
  • CAE1
  • CX50
  • CZP1
  • MP70
  • CTRCT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
protein domain
0.73
cell line
0.49
small molecule perturbation
0.49
biological term
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.78   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.78   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.835
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.834
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.832
Data Source:  STRINGDB
CRYBB2
Tbio
Novelty:  0.00721869
Score:  0.814
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.813
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.802
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.795
Data Source:  STRINGDB
CRYBA1
Tbio
Novelty:  0.02788955
Score:  0.775
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.762
Data Source:  STRINGDB
CRYGD
Tbio
Novelty:  0.00246109
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
79.4
red blood cell density measurement
1
1
1
26.5
hemoglobin measurement
2
1
2
26.1
urate measurement
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
79.4
red blood cell density measurement
1
26.5
hemoglobin measurement
2
26.1
urate measurement
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gap junction protein alpha 8
701415
Mouse
MGI:99953
14616
Rat
RGD:628890
29601
Dog
gap junction protein alpha 8
VGNC:41236
483156
Horse
gap junction protein alpha 8
VGNC:18353
100065084
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gap junction protein alpha 8
Mouse
Rat
Dog
gap junction protein alpha 8
Horse
gap junction protein alpha 8
Publication Statistics
PubMed Score 302.78
PubMed score by year
PubTator Score 193.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title