Protein Summary
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
- ENST00000369110
- ENSP00000358106
- ENSG00000085377
- PEP
- PE
- PEP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
virus perturbation | 0.88 | ||
transcription factor binding site profile | 0.83 | ||
histone modification site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.31 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 199 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.31 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 199 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 253
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0