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Tbio
NPBWR2
Neuropeptides B/W receptor type 2

Protein Summary
Description
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369768
  • ENSP00000358783
  • ENSG00000125522
  • ENST00000612646
  • ENSP00000484253
  • ENSG00000277339

Symbol
  • GPR8
  • GPR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
cell type or tissue
0.58
protein domain
0.58
ligand (protein)
0.46
tissue
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
7
7
90.9
BMI-adjusted waist-hip ratio
2
7
7
90.9
waist-hip ratio
1
4
4
90
waist-hip ratio
1
4
4
90
triglyceride measurement
4
2
4
82.4
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
90.9
BMI-adjusted waist-hip ratio
7
90.9
waist-hip ratio
4
90
waist-hip ratio
4
90
triglyceride measurement
4
82.4
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuropeptides B and W receptor 2
719200
Horse
neuropeptides B and W receptor 2
VGNC:20830
100051823
Anole lizard
neuropeptides B and W receptor 2
100562082
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuropeptides B and W receptor 2
Horse
neuropeptides B and W receptor 2
Anole lizard
neuropeptides B and W receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48146-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (248)
1 – 10 of 248
NPW
Tbio
Novelty:  0.03174263
Score:  0.994
Data Source:  Reactome,STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.992
Data Source:  Reactome,STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.958
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.949
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.948
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.936
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.934
Data Source:  STRINGDB
INSL5
Tbio
Novelty:  0.04351334
Score:  0.932
Data Source:  STRINGDB
RLN3
Tbio
Novelty:  0.0107593
Score:  0.928
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.84

PubMed score by year
PubTator Score  8.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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