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Tchem
SLC6A9
Sodium- and chloride-dependent glycine transporter 1

Protein Summary
Description
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357730
  • ENSP00000350362
  • ENSG00000196517
  • ENST00000360584
  • ENSP00000353791
  • ENST00000372310
  • ENSP00000361384

Symbol
  • GLYT1
  • GCENSG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.95
gene perturbation
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.79


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 647
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (647)
1 – 10 of 647
CHEMBL403515
chemical structure image
CHEMBL392350
chemical structure image
CHEMBL393168
chemical structure image
CHEMBL239605
chemical structure image
CHEMBL394236
chemical structure image
CHEMBL239603
chemical structure image
CHEMBL239601
chemical structure image
CHEMBL239596
chemical structure image
CHEMBL524135
chemical structure image
CHEMBL392586
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
85.2
Cannabis use
1
1
0
1.1
56.9
1
1
0
1.1
56.9
mean corpuscular volume
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
85.2
Cannabis use
0
1.1
56.9
0
1.1
56.9
mean corpuscular volume
1
7.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 9
VGNC:8116
456520
Macaque
solute carrier family 6 member 9
702346
Mouse
MGI:95760
14664
Rat
RGD:621243
116509
Dog
solute carrier family 6 member 9
VGNC:46469
482526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 9
Macaque
solute carrier family 6 member 9
Mouse
Rat
Dog
solute carrier family 6 member 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48067-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Na+/Cl- dependent neurotransmitter transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (40)
1 – 10 of 40
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.997220021
p_ni: 2.17e-7
p_wrong: 0.002779762
Score: 0.188
Data Source: BioPlex,STRINGDB
HMGN3
Tbio
Novelty: 0.07122671
Score: 0.979
Data Source: STRINGDB
GLRA3
Tchem
Family: IC
Novelty: 0.0209653
Score: 0.755
Data Source: STRINGDB
GLRA4
Tdark
Family: IC
Novelty: 0.07586108
Score: 0.755
Data Source: STRINGDB
SLC22A14
Tdark
Family: Transporter
Novelty: 0.3340737
Score: 0.709
Data Source: STRINGDB
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.672
Data Source: STRINGDB
CCDC24
Tdark
Novelty: 1.61025655
Score: 0.669
Data Source: STRINGDB
GLRB
Tclin
Family: IC
Novelty: 0.01721113
Score: 0.665
Data Source: STRINGDB
GLRA1
Tclin
Family: IC
Novelty: 0.00565137
Score: 0.655
Data Source: STRINGDB
SLCO6A1
Tbio
Family: Transporter
Novelty: 0.07836028
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.71

PubMed score by year
PubTator Score  158.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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