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Tchem
SLC6A11
Sodium- and chloride-dependent GABA transporter 3

Protein Summary
Description
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254488
  • ENSP00000254488
  • ENSG00000132164
  • ENST00000454147
  • ENSP00000404120

Symbol
  • GABT3
  • GAT3
  • GAT3
  • GAT4
  • GAT-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
co-expressed gene
0.82
pathway
0.55
PubMedID
0.53
disease
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1