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Tchem
SLC6A12
Sodium- and chloride-dependent betaine transporter

Protein Summary
Description
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359674
  • ENSP00000352702
  • ENSG00000111181
  • ENST00000397296
  • ENSP00000380464
  • ENST00000424061
  • ENSP00000399136
  • ENST00000536824
  • ENSP00000444268

Symbol
  • BGT1
  • GAT2
  • BGT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cell type or tissue
0.63
pathway
0.62
disease perturbation
0.56
transcription factor
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.06   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.06   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1