CXCL12
Stromal cell-derived factor 1
Protein Summary
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ...more
- ENST00000343575
- ENSP00000339913
- ENSG00000107562
- ENST00000374426
- ENSP00000363548
- ENST00000374429
- ENSP00000363551
- ENST00000395793
- ENSP00000379139
- ENST00000395794
- ENSP00000379140
- ENST00000395795
- ENSP00000379141
- SDF1
- SDF1A
- SDF1B
- IRH
- PBSF
- SDF1
- TLSF
- TPAR1
- SCYB12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
PubMedID | 1 | ||
disease perturbation | 0.9 | ||
disease | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4169.66 (req: < 5)
Gene RIFs: 1048 (req: <= 3)
Antibodies: 788 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4169.66 (req: >= 5)
Gene RIFs: 1048 (req: > 3)
Antibodies: 788 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 23
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (23)
Protein-Protein Interactions (581)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (36)
Reactome (17)
KEGG (11)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Developmental Biology | ||||
Reactome | ESR-mediated signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Developmental Biology | ||||
ESR-mediated signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (6)
Components (5)
Processes (43)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
5 | 5 | 2 | 1.1 | 90.9 | |||||
neutrophil count | 2 | 2 | 2 | 87.6 | |||||
myeloid white cell count | 1 | 1 | 1 | 82 | |||||
lymphocyte count | 2 | 3 | 3 | 80.4 | |||||
leukocyte count | 1 | 1 | 1 | 77.3 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.1 | 90.9 | |||||
neutrophil count | 2 | 87.6 | |||||
myeloid white cell count | 1 | 82 | |||||
lymphocyte count | 3 | 80.4 | |||||
leukocyte count | 1 | 77.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:103556 | 20315 | ||||||
Rat | RGD:3651 | 24772 | ||||||
Horse | C-X-C motif chemokine ligand 12 | VGNC:16983 | 100049872 | |||||
Cow | C-X-C motif chemokine ligand 12 | VGNC:27848 | 613811 | |||||
Pig | C-X-C motif chemokine ligand 12 | 494460 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Horse | C-X-C motif chemokine ligand 12 | |||||
Cow | C-X-C motif chemokine ligand 12 | |||||
Pig | C-X-C motif chemokine ligand 12 | |||||
Publication Statistics
PubMed Score 4169.66
PubMed score by year
PubTator Score 2101.61
PubTator score by year
Related Publications
Text Mined References (1194)
GeneRif Annotations (1048)
Items per page:
0 of 0
PMID | Year | Title |
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