Tbio LIMS1 LIM and senescent cell antigen-like-containing domain protein 1

Protein Summary

Description

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P48059
• B2RAJ4
• B7Z483
• B7Z7R3
• B7Z907
• Q53TE0
• Q9BS44

Gene Name

• LIMS1

Ensembl ID

• ENST00000332345
• ENSP00000331775
• ENSG00000169756
• ENST00000338045
• ENSP00000337598
• ENST00000393310
• ENSP00000376987
• ENST00000409441
• ENSP00000387264
• ENST00000410093
• ENSP00000386926
• ENST00000544547
• ENSP00000437912

Symbol

• PINCH
• PINCH1
• PINCH
• PINCH1
• PINCH-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
transcription factor perturbation	0.96
microRNA	0.93
biological process	0.91
transcription factor	0.85

Protein Classes

PANTHER Classes

Protein / Structural Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 1

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Lim And Senescent Cell Antigen-like-containing Domain Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.45   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.45   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0