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Tclin
GRIA4
Glutamate receptor 4

Protein Summary
Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282499
  • ENSP00000282499
  • ENSG00000152578
  • ENST00000393125
  • ENSP00000376833
  • ENST00000428631
  • ENSP00000415551
  • ENST00000530497
  • ENSP00000435775

Symbol
  • GLUR4
  • GLUR4
  • GLURD
  • GluA4
  • GLUR4C
  • NEDSGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
molecular function
0.81
microRNA
0.74
protein domain
0.73
ligand (chemical)
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.13   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.13   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
4
3
8.4
96.9
mathematical ability
3
2
3
92.4
cognitive function measurement
1
1
1
77.2
self reported educational attainment
1
1
1
72.4
Myopia
2
2
0
4.7
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
8.4
96.9
mathematical ability
3
92.4
cognitive function measurement
1
77.2
self reported educational attainment
1
72.4
Myopia
0
4.7
70
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor AMPA type subunit 4
VGNC:11793
466768
Macaque
glutamate ionotropic receptor AMPA type subunit 4
705794
Mouse
MGI:95811
14802
Rat
RGD:61863
29629
Dog
glutamate ionotropic receptor AMPA type subunit 4
VGNC:41483
489427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor AMPA type subunit 4
Macaque
glutamate ionotropic receptor AMPA type subunit 4
Mouse
Rat
Dog
glutamate ionotropic receptor AMPA type subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48058-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (115)
Activation of AMPA receptors (R-HSA-399710)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPA receptors
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of AMPA receptors
Activation of NMDA receptors and postsynaptic events
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Protein-Protein Interactions (164)
1 – 10 of 164
GRIA3
Tclin
Family: IC
Novelty: 0.00584546
p_int: 1
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.991
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.986
Data Source: Reactome,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.981
Data Source: STRINGDB
PRKCG
Tchem
Family: Kinase
Novelty: 0.00291817
Score: 0.98
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.979
Data Source: STRINGDB
PICK1
Tbio
Novelty: 0.0058265
Score: 0.976
Data Source: Reactome,STRINGDB
EPB41L1
Tbio
Novelty: 0.02937451
Score: 0.967
Data Source: STRINGDB
GRIP1
Tbio
Novelty: 0.00343871
Score: 0.964
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  314.13

PubMed score by year
PubTator Score  128.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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