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Tchem
KCNJ6
G protein-activated inward rectifier potassium channel 2

Protein Summary
Description
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000609713
  • ENSP00000477437
  • ENSG00000157542
  • ENST00000645093
  • ENSP00000493772

Symbol
  • GIRK2
  • KATP2
  • KCNJ7
  • BIR1
  • GIRK2
  • KATP2
  • KCNJ7
  • KPLBS
  • GIRK-2
  • KATP-2
  • KIR3.2
  • hiGIRK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
trait
0.75
phenotype
0.7
transcription factor binding site profile
0.66
ligand (chemical)
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.46   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.46   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
clozapine
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amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
haloperidol
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clomipramine
Rendered image for clomipramine
verapamil
Rendered image for verapamil
nortriptyline
Rendered image for nortriptyline
pimozide
Rendered image for pimozide
imipramine
Rendered image for imipramine
maprotiline
Rendered image for maprotiline
Protein-Protein Interactions (123)
MB21D2
Tdark
Novelty:  0.48908631
p_int:  0.99999988
p_ni:  5.3e-8
p_wrong:  6.7e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
HPF1
Tbio
Novelty:  0.2749357
p_int:  0.999982866
p_ni:  0.000017133
p_wrong:  1e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.99934864
p_ni:  0.000651259
p_wrong:  1.01e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
RARG
Tclin
Family:  NR
Novelty:  0.00667159
p_int:  0.998266646
p_ni:  0.001733354
Score:  0.228
Data Source:  BioPlex,STRINGDB
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.962068653
p_ni:  0.037931334
p_wrong:  1.3e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.92046117
p_ni:  0.07953883
Score:  0.179
Data Source:  BioPlex,STRINGDB
LRRC1
Tbio
Novelty:  0.08141846
p_int:  0.899910039
p_ni:  0.100089961
Score:  0.188
Data Source:  BioPlex,STRINGDB
HSDL1
Tbio
Family:  Enzyme
Novelty:  0.24066595
p_int:  0.880384339
p_ni:  0.119612475
p_wrong:  0.000003186
Score:  0.173
Data Source:  BioPlex,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.984
Data Source:  Reactome,STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.975
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (14)
Explore Nearest Tclin Targets
1 – 5 of 14
OXTR
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
CNR1
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
HTR1B
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
Pathways (25)
Activation of G protein gated Potassium channels (R-HSA-1296041)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
G protein gated Potassium channels
Reactome
GABA B receptor activation
Reactome
GABA receptor activation
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
G protein gated Potassium channels
GABA B receptor activation
GABA receptor activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
5
89.7
waist-hip ratio
3
5
5
83.6
waist circumference
1
2
2
72.8
basophil percentage of leukocytes
1
1
1
70.8
basophil count
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
89.7
waist-hip ratio
5
83.6
waist circumference
2
72.8
basophil percentage of leukocytes
1
70.8
basophil count
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily J member 6
693675
Mouse
MGI:104781
16522
Rat
RGD:2959
25743
Dog
potassium voltage-gated channel subfamily J member 6
VGNC:42267
487756
Cow
potassium voltage-gated channel subfamily J member 6
VGNC:53585
520743
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily J member 6
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 6
Cow
potassium voltage-gated channel subfamily J member 6
Publication Statistics
PubMed Score 317.46
PubMed score by year
PubTator Score 111.93
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title