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Tchem
KCNJ4
Inward rectifier potassium channel 4

Protein Summary
Description
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303592
  • ENSP00000306497
  • ENSG00000168135

Symbol
  • IRK3
  • HIR
  • HRK1
  • IRK3
  • HIRK2
  • IRK-3
  • Kir2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cellular component
0.82
hub protein
0.71
gene perturbation
0.68
PubMedID
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.14   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.14   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tenidap
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
65
risk-taking behaviour
1
1
1
20.7
TPE interval measurement
1
1
3
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
65
risk-taking behaviour
1
20.7
TPE interval measurement
3
20.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104743
16520
Rat
RGD:621436
116649
Dog
potassium voltage-gated channel subfamily J member 4
VGNC:42265
481253
Horse
potassium voltage-gated channel subfamily J member 4 [Source:HGNC Symbol;Acc:HGNC:6265]
Pig
potassium voltage-gated channel subfamily J member 4
100523060
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 4
Horse
potassium voltage-gated channel subfamily J member 4 [Source:HGNC Symbol;Acc:HGNC:6265]
Pig
potassium voltage-gated channel subfamily J member 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48050-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Cardiac conduction
Reactome
Classical Kir channels
Reactome
G protein gated Potassium channels
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Cardiac conduction
Classical Kir channels
G protein gated Potassium channels
Protein-Protein Interactions (125)
1 – 10 of 125
GNB1
Tbio
Novelty: 0.02477955
Score: 0.952
Data Source: Reactome,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.938
Data Source: Reactome,STRINGDB
KCNJ2
Tchem
Family: IC
Novelty: 0.00290395
Score: 0.938
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.938
Data Source: Reactome,STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.935
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.927
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.923
Data Source: STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00209684
Score: 0.918
Data Source: STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.917
Data Source: Reactome,STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.914
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  104.14

PubMed score by year
PubTator Score  73.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer