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Tchem
KCNJ1
ATP-sensitive inward rectifier potassium channel 1

Protein Summary
Description
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather tha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324036
  • ENSP00000316233
  • ENSG00000151704
  • ENST00000392664
  • ENSP00000376432
  • ENST00000392665
  • ENSP00000376433
  • ENST00000392666
  • ENSP00000376434
  • ENST00000440599
  • ENSP00000406320

Symbol
  • ROMK1
  • ROMK
  • ROMK1
  • KIR1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase
0.75
tissue sample
0.74
cell type or tissue
0.72
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.76   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.76   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 605
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (605)
1 – 10 of 605
Mg<sup>2+</sup>
no chemical structure image available
Cs<sup>+</sup>
no chemical structure image available
H<sup>+</sup>
no chemical structure image available
CHEMBL3696475
Rendered image for CHEMBL3696475
CHEMBL2146865
Rendered image for CHEMBL2146865
CHEMBL2146866
Rendered image for CHEMBL2146866
CHEMBL2146757
Rendered image for CHEMBL2146757
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
85.1
eosinophil percentage of leukocytes
1
1
1
76
serum urea measurement
1
2
2
74
platelet crit
1
1
1
65.9
heel bone mineral density
2
2
2
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.1
eosinophil percentage of leukocytes
1
76
serum urea measurement
2
74
platelet crit
1
65.9
heel bone mineral density
2
60.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily J member 1
714848
Mouse
MGI:1927248
56379
Rat
RGD:2957
24521
Dog
potassium voltage-gated channel subfamily J member 1
VGNC:42258
489285
Horse
potassium voltage-gated channel subfamily J member 1
VGNC:19283
100072580
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily J member 1
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 1
Horse
potassium voltage-gated channel subfamily J member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48048-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Inwardly rectifying K+ channels (R-HSA-1296065)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inwardly rectifying K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Potassium transport channels
Name
Explore in Pharos
Explore in Source
Inwardly rectifying K+ channels
Neuronal System
Potassium Channels
Potassium transport channels
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.972
Data Source:  STRINGDB
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.907
Data Source:  STRINGDB
SLC12A1
Tclin
Family:  Transporter
Novelty:  0.00303604
Score:  0.906
Data Source:  STRINGDB
CLCNKB
Tchem
Family:  IC
Novelty:  0.00982208
Score:  0.871
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.811
Data Source:  STRINGDB
BSND
Tbio
Novelty:  0.01638636
Score:  0.808
Data Source:  STRINGDB
SLC12A3
Tclin
Family:  Transporter
Novelty:  0.00199394
Score:  0.807
Data Source:  STRINGDB
SCNN1A
Tclin
Family:  IC
Novelty:  0.00900102
Score:  0.726
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.711
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.707
Data Source:  STRINGDB
Publication Statistics
PubMed Score  405.76

PubMed score by year
PubTator Score  198.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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