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Tbio
ATP5PO
ATP synthase subunit O, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290299
  • ENSP00000290299
  • ENSG00000241837

Symbol
  • ATP5O
  • ATPO
  • ATPO
  • OSCP
  • ATP5O
  • HMC08D05
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
4
6
95.7
hemoglobin measurement
3
4
5
95.1
platelet crit
1
1
1
70.9
platelet count
1
1
1
70
urate measurement
2
2
2
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
95.7
hemoglobin measurement
5
95.1
platelet crit
1
70.9
platelet count
1
70
urate measurement
2
55.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit OSCP
VGNC:49020
473976
Macaque
ATP synthase peripheral stalk subunit OSCP
698480
Mouse
MGI:106341
28080
Rat
RGD:621379
192241
Dog
ATP synthase peripheral stalk subunit OSCP
100855541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit OSCP
Macaque
ATP synthase peripheral stalk subunit OSCP
Mouse
Rat
Dog
ATP synthase peripheral stalk subunit OSCP
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48047-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
ProtInc
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (261)
1 – 10 of 261
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.997067452
p_ni:  0.002932548
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.977534975
p_ni:  0.022465025
Score:  0.999
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.970271792
p_ni:  0.029728208
Score:  0.239
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.954326281
p_ni:  0.045673719
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACKR3
Tchem
Family:  GPCR
Novelty:  0.00727792
p_int:  0.941957117
p_ni:  0.058042883
Score:  0.835
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.810140331
p_ni:  0.189859669
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.999
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.999
Data Source:  STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.999
Data Source:  STRINGDB
ATP5MG
Tbio
Family:  Enzyme
Novelty:  0.16555751
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  104.21

PubMed score by year
PubTator Score  64.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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