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Tclin
MTNR1A
Melatonin receptor type 1A

Protein Summary
Description
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307161
  • ENSP00000302811
  • ENSG00000168412

Symbol
  • MT1
  • MEL-1A-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.78
gene perturbation
0.74
biological term
0.66
cell type or tissue
0.63
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.58   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.58   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 580
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (263)
1 – 10 of 263
GNB1
Tbio
Novelty: 0.04716243
Score: 0.94
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
Score: 0.939
Data Source: STRINGDB
MTNR1B
Tclin
Family: GPCR
Novelty: 0.00391188
Score: 0.937
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03936457
Score: 0.937
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.932
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.1530232
Score: 0.928
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.924
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.923
Data Source: STRINGDB
TMIGD3
Tchem
Novelty: 0.00111452
Score: 0.922
Data Source: STRINGDB
ADORA3
Tchem
Family: GPCR
Novelty: 0.00111452
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  218.58

PubMed score by year
PubTator Score  70.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer