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Tclin
MTNR1A
Melatonin receptor type 1A

Protein Summary
Description
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307161
  • ENSP00000302811
  • ENSG00000168412

Symbol
  • MT1
  • MEL-1A-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.78
gene perturbation
0.74
biological term
0.66
cell type or tissue
0.63
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.37   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.37   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 655
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (263)
GNB1
Tbio
Novelty:  0.02477955
Score:  0.94
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.939
Data Source:  STRINGDB
MTNR1B
Tclin
Family:  GPCR
Novelty:  0.00646326
Score:  0.937
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.937
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.932
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.928
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.924
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.923
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.922
Data Source:  STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
60.8
reticulocyte count
1
1
1
42.3
Calcium channel blocker use measurement
1
1
1
17.8
job-related exhaustion measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
60.8
reticulocyte count
1
42.3
Calcium channel blocker use measurement
1
17.8
job-related exhaustion measurement
1
14.2
Find similar targets by:
IDG Resources
Mouse
image for
Details:
  • Allele:  Insertion
Genetic Construct
MTNR1A-Tango
image for MTNR1A-Tango
Details:
  • Vector:  addgene66443
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • MTNR1A-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melatonin receptor 1A
471417
Macaque
melatonin receptor 1A
702686
Mouse
MGI:102967
17773
Rat
RGD:620797
114211
Horse
melatonin receptor 1A
VGNC:20432
100056423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melatonin receptor 1A
Macaque
melatonin receptor 1A
Mouse
Rat
Horse
melatonin receptor 1A
Publication Statistics
PubMed Score 105.37
PubMed score by year
PubTator Score 70.24
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title