Tclin MTNR1A Melatonin receptor type 1A

Protein Summary

Description

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48039
• A0AVC5
• B0M0L2
• Mel-1A-R

Gene Name

• MTNR1A

Ensembl ID

• ENST00000307161
• ENSP00000302811
• ENSG00000168412

Symbol

• MT1
• MEL-1A-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.78
gene perturbation	0.74
biological term	0.66
cell type or tissue	0.63
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Melatonin Receptor Type 1a

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Melatonin Receptor / Melatonin Receptor Type 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.05   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.05   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 680

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4