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Tbio
FASLG
Tumor necrosis factor ligand superfamily member 6

Protein Summary
Description
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260). FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340030
  • ENSP00000344739
  • ENSG00000117560
  • ENST00000367721
  • ENSP00000356694

Symbol
  • APT1LG1
  • CD95L
  • FASL
  • TNFSF6
  • APTL
  • FASL
  • CD178
  • CD95L
  • ALPS1B
  • CD95-L
  • TNFSF6
  • TNLG1A
  • APT1LG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
chemical
0.99
hub protein
0.88
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3164.68   (req: < 5)
Gene RIFs: 549   (req: <= 3)
Antibodies: 1202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3164.68   (req: >= 5)
Gene RIFs: 549   (req: > 3)
Antibodies: 1202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0