Tbio FASLG Tumor necrosis factor ligand superfamily member 6

Protein Summary

Description

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260). FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P48023
• Q9BZP9

Gene Name

• FASLG

Ensembl ID

• ENST00000340030
• ENSP00000344739
• ENSG00000117560
• ENST00000367721
• ENSP00000356694

Symbol

• APT1LG1
• CD95L
• FASL
• TNFSF6
• APTL
• FASL
• CD178
• CD95L
• ALPS1B
• CD95-L
• TNFSF6
• TNLG1A
• APT1LG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
biological process	0.99
chemical	0.99
hub protein	0.88
cellular component	0.78

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Tumor Necrosis Factor Family Member / Tumor Necrosis Factor Ligand Superfamily Member 6

DTO Classes

Protein / Signaling / Cytokine / Tumor Necrosis Factor Family Member / Tumor Necrosis Factor Ligand Superfamily Member 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3164.68   (req: < 5)

Gene RIFs: 552   (req: <= 3)

Antibodies: 1202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3164.68   (req: >= 5)

Gene RIFs: 552   (req: > 3)

Antibodies: 1202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0