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Tbio
XCL1
Lymphotactin

Protein Summary
Description
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367818
  • ENSP00000356792
  • ENSG00000143184

Symbol
  • LTN
  • SCYC1
  • LTN
  • ATAC
  • LPTN
  • SCM1
  • SCM-1
  • SCM1A
  • SCYC1
  • SCM-1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.75
tissue sample
0.72
kinase perturbation
0.6
microRNA
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.73   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.73   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (255)
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.998515394
p_ni:  0.001484606
Score:  0.169
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.970244491
p_ni:  0.029755509
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.966784159
p_ni:  0.033215841
Data Source:  BioPlex
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.884573965
p_ni:  0.115426035
Score:  0.165
Data Source:  BioPlex,STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
p_int:  0.803892178
p_ni:  0.196107822
Score:  0.177
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.788816647
p_ni:  0.211183353
Score:  0.165
Data Source:  BioPlex,STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.763242438
p_ni:  0.228396289
p_wrong:  0.008361273
Score:  0.189
Data Source:  BioPlex,STRINGDB
XCR1
Tbio
Family:  GPCR
Novelty:  0.00971657
Score:  0.996
Data Source:  Reactome,STRINGDB
XCL2
Tbio
Novelty:  0.05252386
Score:  0.954
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (12)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hepatitis
1
1
0
1.2
7.4
1
1
1
5
electrocardiography
1
1
13
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hepatitis
0
1.2
7.4
1
5
electrocardiography
13
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104593
16963
Rat
RGD:620452
171371
Dog
cytokine SCM-1 beta
490356
Horse
X-C motif chemokine ligand 1
100057696
Cow
chemokine (C motif) ligand 2
100295210
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cytokine SCM-1 beta
Horse
X-C motif chemokine ligand 1
Cow
chemokine (C motif) ligand 2
Publication Statistics
PubMed Score 249.73
PubMed score by year
PubTator Score 134.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title