XCL1
Lymphotactin
Protein Summary
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
- ENST00000367818
- ENSP00000356792
- ENSG00000143184
- LTN
- SCYC1
- LTN
- ATAC
- LPTN
- SCM1
- SCM-1
- SCM1A
- SCYC1
- SCM-1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
gene perturbation | 0.75 | ||
tissue sample | 0.72 | ||
kinase perturbation | 0.6 | ||
microRNA | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 289.2 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 289.2 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 51
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0