Protein Summary
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
- ENST00000367818
- ENSP00000356792
- ENSG00000143184
- LTN
- SCYC1
- LTN
- ATAC
- LPTN
- SCM1
- SCM-1
- SCM1A
- SCYC1
- SCM-1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
gene perturbation | 0.75 | ||
tissue sample | 0.72 | ||
kinase perturbation | 0.6 | ||
microRNA | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.73 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.73 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 51
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (255)
FAT4
Novelty: 0.01739918
p_int: 0.998515394
p_ni: 0.001484606
Score: 0.169
Data Source: BioPlex,STRINGDB
FAT3
Novelty: 0.03661008
p_int: 0.884573965
p_ni: 0.115426035
Score: 0.165
Data Source: BioPlex,STRINGDB
COL6A2
Novelty: 0.01275082
p_int: 0.803892178
p_ni: 0.196107822
Score: 0.177
Data Source: BioPlex,STRINGDB
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.788816647
p_ni: 0.211183353
Score: 0.165
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00557848
p_int: 0.763242438
p_ni: 0.228396289
p_wrong: 0.008361273
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (12)
Reactome (8)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (4)
Components (3)
Processes (47)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Hepatitis | 1 | 1 | 0 | 1.2 | 7.4 | ||||
1 | 1 | 1 | 5 | ||||||
electrocardiography | 1 | 1 | 13 | 3.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Hepatitis | 0 | 1.2 | 7.4 | ||||
1 | 5 | ||||||
electrocardiography | 13 | 3.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:104593 | 16963 | ||||||
Rat | RGD:620452 | 171371 | ||||||
Dog | cytokine SCM-1 beta | 490356 | ||||||
Horse | X-C motif chemokine ligand 1 | 100057696 | ||||||
Cow | chemokine (C motif) ligand 2 | 100295210 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | cytokine SCM-1 beta | |||||
Horse | X-C motif chemokine ligand 1 | |||||
Cow | chemokine (C motif) ligand 2 | |||||
Publication Statistics
PubMed Score 249.73
PubMed score by year
PubTator Score 134.56
PubTator score by year
Related Publications
Text Mined References (52)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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