Protein Classes
Protein Summary
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
- ENST00000367818
- ENSP00000356792
- ENSG00000143184
- LTN
- SCYC1
- LTN
- ATAC
- LPTN
- SCM1
- SCM-1
- SCM1A
- SCYC1
- SCM-1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
gene perturbation | 0.75 | ||
tissue sample | 0.72 | ||
kinase perturbation | 0.6 | ||
microRNA | 0.55 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 351.07 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 351.07 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 51
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (12)
Reactome (8)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Gene Ontology Terms (54)
Functions (4)
Components (3)
Processes (47)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (255)
1 – 10 of 255
FAT4
Novelty: 0.01665267
p_int: 0.998515394
p_ni: 0.001484606
Score: 0.169
Data Source: BioPlex,STRINGDB
TUBB8
Novelty: 0.11569363
p_int: 0.970244491
p_ni: 0.029755509
Data Source: BioPlex
TUBB3
Novelty: 0.00281462
p_int: 0.966784159
p_ni: 0.033215841
Data Source: BioPlex
FAT3
Novelty: 0.02603864
p_int: 0.884573965
p_ni: 0.115426035
Score: 0.165
Data Source: BioPlex,STRINGDB
COL6A2
Novelty: 0.01825304
p_int: 0.803892178
p_ni: 0.196107822
Score: 0.177
Data Source: BioPlex,STRINGDB
ADGRV1
Family: GPCR
Novelty: 0.00291831
p_int: 0.788816647
p_ni: 0.211183353
Score: 0.165
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00842838
p_int: 0.763242438
p_ni: 0.228396289
p_wrong: 0.008361273
Score: 0.189
Data Source: BioPlex,STRINGDB
XCR1
Family: GPCR
Novelty: 0.01497998
Score: 0.996
Data Source: Reactome,STRINGDB
XCL2
Novelty: 0.072835
Score: 0.954
Data Source: STRINGDB
P2RY10
Family: GPCR
Novelty: 0.30443923
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score 351.07
PubMed score by year
PubTator Score 134.56
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCA
1-70
DPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG
70-114
MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG
Find similar targets by: