Tbio XCL1 Lymphotactin

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Lymphotactin

DTO Classes

Protein / Signaling / Chemokine / Lymphotactin

Protein Summary

Description

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P47992
• Q52MA8

Gene Name

• XCL1

Ensembl ID

• ENST00000367818
• ENSP00000356792
• ENSG00000143184

Symbol

• LTN
• SCYC1
• LTN
• ATAC
• LPTN
• SCM1
• SCM-1
• SCM1A
• SCYC1
• SCM-1a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	0.75
tissue sample	0.72
kinase perturbation	0.6
microRNA	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.07   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.07   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (6)

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (12)

Reactome (8)

KEGG (3)

WikiPathways (1)

Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (54)

Functions (4)

Components (3)

Processes (47)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
chemokine activity	Inferred from Direct Assay (IDA)	BHF-UCL
chemokine receptor binding	Inferred from Direct Assay (IDA)	BHF-UCL
protein homodimerization activity	Inferred from Direct Assay (IDA)	BHF-UCL
CCR chemokine receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (255)

Explore Interacting Targets

1 – 10 of 255

• See Interactions on String-DB

FAT4

Tbio

Novelty: 0.01665267

p_int: 0.998515394

p_ni: 0.001484606

Score: 0.169

Data Source: BioPlex,STRINGDB

TUBB8

Tclin

Novelty: 0.11569363

p_int: 0.970244491

p_ni: 0.029755509

Data Source: BioPlex

TUBB3

Tclin

Novelty: 0.00281462

p_int: 0.966784159

p_ni: 0.033215841

Data Source: BioPlex

FAT3

Tbio

Novelty: 0.02603864

p_int: 0.884573965

p_ni: 0.115426035

Score: 0.165

Data Source: BioPlex,STRINGDB

COL6A2

Tbio

Novelty: 0.01825304

p_int: 0.803892178

p_ni: 0.196107822

Score: 0.177

Data Source: BioPlex,STRINGDB

ADGRV1

Tbio

Family: GPCR

Novelty: 0.00291831

p_int: 0.788816647

p_ni: 0.211183353

Score: 0.165

Data Source: BioPlex,STRINGDB

FSTL1

Tbio

Novelty: 0.00842838

p_int: 0.763242438

p_ni: 0.228396289

p_wrong: 0.008361273

Score: 0.189

Data Source: BioPlex,STRINGDB

XCR1

Tbio

Family: GPCR

Novelty: 0.01497998

Score: 0.996

Data Source: Reactome,STRINGDB

XCL2

Tbio

Novelty: 0.072835

Score: 0.954

Data Source: STRINGDB

P2RY10

Tchem

Family: GPCR

Novelty: 0.30443923

Score: 0.92

Data Source: STRINGDB

Publication Statistics

PubMed Score  351.07

PubMed score by year

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PubTator Score  134.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCA

1-70

DPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

70-114

MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

Find similar targets by:

Uniprot Keyword

3D-structure
Chemotaxis
Complete proteome
Cytokine
Disulfide bond
Reference proteome
Secreted
Signal