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Tclin
XDH
Xanthine dehydrogenase/oxidase

Protein Classes
Protein Summary
Description
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379416
  • ENSP00000368727
  • ENSG00000158125

Symbol
  • XDHA
  • XO
  • XOR
  • XAN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
biological process
0.97
chemical
0.97
drug
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1970.43   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1970.43   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
2
2
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
2
77.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
xanthine dehydrogenase
VGNC:423
470347
Mouse
MGI:98973
22436
Rat
RGD:62043
497811
Dog
xanthine dehydrogenase
VGNC:48448
483028
Horse
xanthine dehydrogenase/oxidase
100054601
Species
Name
OMA
EggNOG
Inparanoid
Chimp
xanthine dehydrogenase
Mouse
Rat
Dog
xanthine dehydrogenase
Horse
xanthine dehydrogenase/oxidase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47989-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (90)
1 – 10 of 90
CCDC110
Tbio
Novelty: 0.11479518
p_int: 0.833742691
p_ni: 0.000013141
p_wrong: 0.166244168
Score: 0.692
Data Source: BioPlex,STRINGDB
BTN1A1
Tbio
Novelty: 0.0067071
Score: 0.975
Data Source: Reactome,STRINGDB
GDA
Tbio
Family: Enzyme
Novelty: 0.01846276
Score: 0.959
Data Source: STRINGDB
PNP
Tclin
Family: Enzyme
Novelty: 0.0019084
Score: 0.951
Data Source: STRINGDB
TPMT
Tchem
Family: Enzyme
Novelty: 0.00272111
Score: 0.933
Data Source: STRINGDB
HPRT1
Tchem
Family: Enzyme
Novelty: 0.00032232
Score: 0.929
Data Source: STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
Score: 0.916
Data Source: STRINGDB
NAT2
Tbio
Family: Enzyme
Novelty: 0.00150849
Score: 0.909
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.907
Data Source: STRINGDB
RBP1
Tbio
Novelty: 0.00199929
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  1970.43

PubMed score by year
PubTator Score  828.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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