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Tbio
UQCRFS1
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Protein Summary
Description
Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544). Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer, including this fragment, called subunit 9, which corresponds to the transit peptide (PubMed:28673544). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304863
  • ENSP00000306397
  • ENSG00000169021

Symbol
  • RIP1
  • RIS1
  • RISP
  • UQCR5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.93
protein domain
0.92
co-expressed gene
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
LYRM7
Tbio
Novelty:  0.16270565
p_int:  0.999905862
p_ni:  0.000094138
Score:  0.742
Data Source:  BioPlex,STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.999816252
p_ni:  0.000183748
Score:  0.201
Data Source:  BioPlex,STRINGDB
UQCRC2
Tbio
Family:  Enzyme
Novelty:  0.01584406
Score:  0.999
Data Source:  STRINGDB
UQCRB
Tbio
Novelty:  0.02933046
Score:  0.999
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.999
Data Source:  STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
Score:  0.999
Data Source:  STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
Score:  0.999
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.999
Data Source:  STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
Score:  0.999
Data Source:  STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
741344
Macaque
cytochrome b-c1 complex subunit Rieske, mitochondrial
700087
Mouse
MGI:1913944
66694
Rat
RGD:628838
291103
Dog
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VGNC:53998
476503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Macaque
cytochrome b-c1 complex subunit Rieske, mitochondrial
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Publication Statistics
PubMed Score 284.88
PubMed score by year
PubTator Score 22.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title