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Tbio
NPTX2
Neuronal pentraxin-2

Protein Summary
Description
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265634
  • ENSP00000265634
  • ENSG00000106236

Symbol
  • NP2
  • NARP
  • NP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.9
kinase perturbation
0.81
disease perturbation
0.62
transcription factor
0.62
disease
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.78   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.78   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (60)
1 – 10 of 60
CYB5D2
Tdark
Novelty: 0.25907026
p_int: 0.999999992
p_ni: 7e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
NPTX1
Tbio
Novelty: 0.03619614
p_int: 0.999919176
p_ni: 0.000080824
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00522455
p_int: 0.999779561
p_ni: 0.000192625
p_wrong: 0.000027814
Data Source: BioPlex
NDE1
Tbio
Novelty: 0.01199577
p_int: 0.999570274
p_ni: 0.000429726
Data Source: BioPlex
NPTXR
Tbio
Novelty: 0.00192354
p_int: 0.998107701
p_ni: 0.001889646
p_wrong: 0.000002653
Score: 0.453
Data Source: BioPlex,STRINGDB
NDEL1
Tbio
Novelty: 0.01425912
p_int: 0.997789094
p_ni: 0.002210906
Data Source: BioPlex
RGPD5
Tdark
Novelty: 0.26241703
p_int: 0.98018775
p_ni: 0.01981225
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01598375
p_int: 0.959232874
p_ni: 0.040764902
p_wrong: 0.000002224
Data Source: BioPlex
MAPK3
Tchem
Family: Kinase
Novelty: 0.0001911
p_int: 0.936298848
p_ni: 0.063701152
Data Source: BioPlex
BATF3
Tbio
Family: TF
Novelty: 0.01678998
p_int: 0.877975114
p_ni: 0.001032095
p_wrong: 0.120992791
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  233.78

PubMed score by year
PubTator Score  144.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer