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Tbio
LGALS7
Galectin-7

Protein Summary
Description
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314980
  • ENSP00000313571
  • ENSG00000178934
  • ENST00000378626
  • ENSP00000367891
  • ENSG00000205076
  • ENST00000634448
  • ENSP00000489395
  • ENSG00000282902
  • ENST00000634800
  • ENSP00000489582
  • ENSG00000283082

Symbol
  • PIG1
  • GAL7
  • LGALS7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease
0.59
cellular component
0.55
protein complex
0.53
cell line
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.88   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.88   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.997363451
p_ni:  0.00216947
p_wrong:  0.000467079
Data Source:  BioPlex
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
p_int:  0.995252467
p_ni:  0.004747533
Score:  0.489
Data Source:  BioPlex,STRINGDB
DPYSL4
Tbio
Family:  Enzyme
Novelty:  0.0449179
p_int:  0.993331433
p_ni:  0.006668566
p_wrong:  2e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
p_int:  0.99185746
p_ni:  0.00814254
Score:  0.169
Data Source:  BioPlex,STRINGDB
DPYSL2
Tbio
Family:  Enzyme
Novelty:  0.00374969
p_int:  0.991011856
p_ni:  0.008988144
Score:  0.19
Data Source:  BioPlex,STRINGDB
GAB1
Tchem
Novelty:  0.02174353
p_int:  0.989097478
p_ni:  0.010902515
p_wrong:  8e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.988825165
p_ni:  0.011174835
Data Source:  BioPlex
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
p_int:  0.983827907
p_ni:  0.016164656
p_wrong:  0.000007437
Score:  0.179
Data Source:  BioPlex,STRINGDB
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
p_int:  0.974403799
p_ni:  0.025596195
p_wrong:  6e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
86
platelet count
4
4
4
85.1
blood protein measurement
2
2
2
83.2
blood protein measurement
2
2
2
83.2
SIR2-like protein 2 measurement
1
1
1
82.5
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
86
platelet count
4
85.1
blood protein measurement
2
83.2
blood protein measurement
2
83.2
SIR2-like protein 2 measurement
1
82.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1316742
16858
Rat
RGD:61951
29518
Dog
galectin 7
100686721
Horse
galectin-7
100066399
Cow
galectin 7
787811
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
galectin 7
Horse
galectin-7
Cow
galectin 7
Publication Statistics
PubMed Score 146.88
PubMed score by year
PubTator Score 88.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title