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Tbio
LGALS7
Galectin-7

Protein Summary
Description
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314980
  • ENSP00000313571
  • ENSG00000178934
  • ENST00000378626
  • ENSP00000367891
  • ENSG00000205076
  • ENST00000634448
  • ENSP00000489395
  • ENSG00000282902
  • ENST00000634800
  • ENSP00000489582
  • ENSG00000283082

Symbol
  • PIG1
  • GAL7
  • LGALS7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease
0.59
cellular component
0.55
protein complex
0.53
cell line
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.17   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.17   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1316742
16858
Rat
RGD:61951
29518
Dog
galectin 7
100686721
Horse
galectin-7
100066399
Cow
galectin 7
787811
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
galectin 7
Horse
galectin-7
Cow
galectin 7
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47929-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (98)
1 – 10 of 98
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.999999887
p_ni: 1.13e-7
Data Source: BioPlex
USP4
Tbio
Family: Enzyme
Novelty: 0.01101075
p_int: 0.997363451
p_ni: 0.00216947
p_wrong: 0.000467079
Data Source: BioPlex
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
p_int: 0.995252467
p_ni: 0.004747533
Score: 0.489
Data Source: BioPlex,STRINGDB
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
p_int: 0.993331433
p_ni: 0.006668566
p_wrong: 2e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
NAMPT
Tchem
Family: Enzyme
Novelty: 0.00093316
p_int: 0.99185746
p_ni: 0.00814254
Score: 0.169
Data Source: BioPlex,STRINGDB
DPYSL2
Tbio
Family: Enzyme
Novelty: 0.00374969
p_int: 0.991011856
p_ni: 0.008988144
Score: 0.19
Data Source: BioPlex,STRINGDB
GAB1
Tbio
Novelty: 0.02174353
p_int: 0.989097478
p_ni: 0.010902515
p_wrong: 8e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.988825165
p_ni: 0.011174835
Data Source: BioPlex
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
p_int: 0.983827907
p_ni: 0.016164656
p_wrong: 0.000007437
Score: 0.179
Data Source: BioPlex,STRINGDB
POLA2
Tbio
Family: Enzyme
Novelty: 0.07371844
p_int: 0.974403799
p_ni: 0.025596195
p_wrong: 6e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  128.17

PubMed score by year
PubTator Score  88.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer