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Tbio
ID4
DNA-binding protein inhibitor ID-4

Protein Summary
Description
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378700
  • ENSP00000367972
  • ENSG00000172201

Symbol
  • BHLHB27
  • IDB4
  • bHLHb27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.99
biological process
0.91
gene perturbation
0.91
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.42   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.42   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999996809
p_ni:  1.2e-8
p_wrong:  0.00000318
Score:  0.886
Data Source:  BioPlex,STRINGDB
METTL2A
Tdark
Family:  Enzyme
Novelty:  0.72443397
p_int:  0.999959863
p_ni:  0.000013753
p_wrong:  0.000026384
Score:  0.188
Data Source:  BioPlex,STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
p_int:  0.99994069
p_ni:  0.000057752
p_wrong:  0.000001558
Score:  0.703
Data Source:  BioPlex,STRINGDB
MYF6
Tbio
Family:  TF
Novelty:  0.00509046
p_int:  0.999896469
p_ni:  0.000100174
p_wrong:  0.000003357
Score:  0.729
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.995320304
p_ni:  0.000096025
p_wrong:  0.004583671
Score:  0.588
Data Source:  BioPlex,STRINGDB
MYOG
Tbio
Family:  TF
Novelty:  0.00074867
p_int:  0.782555675
p_ni:  0.000538307
p_wrong:  0.216906018
Score:  0.838
Data Source:  BioPlex,STRINGDB
OLIG1
Tbio
Family:  TF
Novelty:  0.01006324
Score:  0.88
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.765
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.735
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.706
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
4
6
95.2
BMI-adjusted waist circumference
2
2
3
88.2
body weights and measures
1
1
1
87.6
body fat distribution
2
1
4
82.1
body height
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
95.2
BMI-adjusted waist circumference
3
88.2
body weights and measures
1
87.6
body fat distribution
4
82.1
body height
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inhibitor of DNA binding 4, HLH protein
705825
Mouse
MGI:99414
15904
Rat
RGD:631428
291023
Horse
inhibitor of DNA binding 4, HLH protein [Source:HGNC Symbol;Acc:HGNC:5363]
Pig
inhibitor of DNA binding 4, HLH protein
100144508
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inhibitor of DNA binding 4, HLH protein
Mouse
Rat
Horse
inhibitor of DNA binding 4, HLH protein [Source:HGNC Symbol;Acc:HGNC:5363]
Pig
inhibitor of DNA binding 4, HLH protein
Publication Statistics
PubMed Score 268.42
PubMed score by year
PubTator Score 124.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title