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Tbio
RPL29
60S ribosomal protein L29

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294189
  • ENSP00000294189
  • ENSG00000162244
  • ENST00000466397
  • ENSP00000418868
  • ENST00000475248
  • ENSP00000417048
  • ENST00000479017
  • ENSP00000418153
  • ENST00000492277
  • ENSP00000418346
  • ENST00000495383
  • ENSP00000420673

Symbol
  • HIP
  • L29
  • HUMRPL29
  • RPL29P10
  • RPL29_3_370
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.89
transcription factor perturbation
0.84
biological process
0.73
tissue
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
6.8
low density lipoprotein cholesterol measurement
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
6.8
low density lipoprotein cholesterol measurement
1
3.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L29-like
704510
Horse
ribosomal protein L29
VGNC:22527
100052055
Cow
ribosomal protein L29
VGNC:34115
507270
Pig
ribosomal protein L29
396993
Fruitfly
FBgn0016726
37430
Species
Name
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L29-like
Horse
ribosomal protein L29
Cow
ribosomal protein L29
Pig
ribosomal protein L29
Fruitfly
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (381)
1 – 10 of 381
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.961963823
p_ni: 0.038036177
Data Source: BioPlex
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.866197413
p_ni: 0.133802587
Data Source: BioPlex
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.832182233
p_ni: 0.16781763
p_wrong: 1.37e-7
Score: 0.27
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.817336471
p_ni: 0.182627642
p_wrong: 0.000035887
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.754157427
p_ni: 0.245842572
Score: 0.866
Data Source: BioPlex,STRINGDB
RPL34
Tbio
Novelty: 0.02236592
Score: 0.999
Data Source: STRINGDB
RPL32
Tbio
Novelty: 0.00279161
Score: 0.999
Data Source: STRINGDB
RPL30
Tbio
Novelty: 0.0134194
Score: 0.999
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.999
Data Source: STRINGDB
RPL35
Tbio
Novelty: 0.03722634
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.58

PubMed score by year
PubTator Score  43.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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