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Tbio
RPL29
60S ribosomal protein L29

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294189
  • ENSP00000294189
  • ENSG00000162244
  • ENST00000466397
  • ENSP00000418868
  • ENST00000475248
  • ENSP00000417048
  • ENST00000479017
  • ENSP00000418153
  • ENST00000492277
  • ENSP00000418346
  • ENST00000495383
  • ENSP00000420673

Symbol
  • HIP
  • L29
  • HUMRPL29
  • RPL29P10
  • RPL29_3_370
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.89
transcription factor perturbation
0.84
biological process
0.73
tissue
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (381)
1 – 10 of 381
H1FOO
Tbio
Novelty: 0.02925688
p_int: 0.961963823
p_ni: 0.038036177
Data Source: BioPlex
MECP2
Tchem
Family: TF
Novelty: 0.00058175
p_int: 0.866197413
p_ni: 0.133802587
Data Source: BioPlex
RRS1
Tbio
Novelty: 0.00929224
p_int: 0.832182233
p_ni: 0.16781763
p_wrong: 1.37e-7
Score: 0.27
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03125092
p_int: 0.817336471
p_ni: 0.182627642
p_wrong: 0.000035887
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 2.35714286
p_int: 0.754157427
p_ni: 0.245842572
Score: 0.866
Data Source: BioPlex,STRINGDB
RPL34
Tbio
Novelty: 0.00119451
Score: 0.999
Data Source: STRINGDB
RPL32
Tbio
Novelty: 0.00584751
Score: 0.999
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.999
Data Source: STRINGDB
RPL30
Tbio
Novelty: 0.0256669
Score: 0.999
Data Source: STRINGDB
RPL35
Tbio
Novelty: 0.04681864
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  79.15

PubMed score by year
PubTator Score  43.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAE
1-70
AIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAP
70-140
ASVPAQAPKRTQAPTKASE
140-159
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE