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Tbio
CDX1
Homeobox protein CDX-1

Protein Summary
Description
Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536). This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231656
  • ENSP00000231656
  • ENSG00000113722
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.79
PubMedID
0.67
cell type or tissue
0.57
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.37   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.37   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
CABIN1
Tbio
Novelty:  0.02528794
p_int:  0.999997233
p_ni:  0.000002767
Data Source:  BioPlex
HIRA
Tbio
Novelty:  0.01362595
p_int:  0.99994318
p_ni:  0.00005682
Data Source:  BioPlex
DHX29
Tbio
Family:  Enzyme
Novelty:  0.06866329
p_int:  0.999929267
p_ni:  0.000002352
p_wrong:  0.00006838
Score:  0.187
Data Source:  BioPlex,STRINGDB
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999889442
p_ni:  0.00010941
p_wrong:  0.000001148
Data Source:  BioPlex
UBN2
Tbio
Novelty:  0.09777456
p_int:  0.999858599
p_ni:  0.000141399
p_wrong:  2e-9
Data Source:  BioPlex
TUT7
Tbio
Family:  Enzyme
Novelty:  0.06274003
p_int:  0.999804203
p_ni:  0.000195797
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZNF724
Tdark
Family:  TF
Novelty:  21.16304348
p_int:  0.999086164
p_ni:  0.000544161
p_wrong:  0.000369675
Score:  0.185
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999048723
p_ni:  0.000951265
p_wrong:  1.1e-8
Score:  0.246
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.998949936
p_ni:  0.001049746
p_wrong:  3.18e-7
Score:  0.399
Data Source:  BioPlex,STRINGDB
KBTBD6
Tdark
Novelty:  1.06955768
p_int:  0.998192606
p_ni:  0.001807394
Score:  0.38
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
6
6
99.1
monocyte count
2
3
3
97.8
granulocyte percentage of myeloid white cells
1
2
2
91.2
blood protein measurement
1
1
1
31.4
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
6
99.1
monocyte count
3
97.8
granulocyte percentage of myeloid white cells
2
91.2
blood protein measurement
1
31.4
0
1.1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caudal type homeobox 1
VGNC:11880
471693
Mouse
MGI:88360
12590
Dog
caudal type homeobox 1
VGNC:39084
612256
Pig
caudal type homeobox 1
100626275
Opossum
caudal type homeobox 1
100024158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caudal type homeobox 1
Mouse
Dog
caudal type homeobox 1
Pig
caudal type homeobox 1
Opossum
caudal type homeobox 1
Publication Statistics
PubMed Score 125.37
PubMed score by year
PubTator Score 85.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title