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Tclin
AVPR1B
Vasopressin V1b receptor

Protein Summary
Description
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367126
  • ENSP00000356094
  • ENSG00000198049

Symbol
  • AVPR3
  • VPR3
  • V1bR
  • AVPR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.95
cell type or tissue
0.8
co-expressed gene
0.65
molecular function
0.63
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.31   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.31   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 99
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
arginine vasopressin receptor 1B
695963
Mouse
MGI:1347010
26361
Dog
arginine vasopressin receptor 1B
VGNC:38319
488578
Horse
arginine vasopressin receptor 1B
VGNC:15711
100055260
Cow
arginine vasopressin receptor 1B
VGNC:26359
282861
Species
Name
OMA
EggNOG
Inparanoid
Macaque
arginine vasopressin receptor 1B
Mouse
Dog
arginine vasopressin receptor 1B
Horse
arginine vasopressin receptor 1B
Cow
arginine vasopressin receptor 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47901-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Disease
Disorders of transmembrane transporters
G alpha (q) signalling events
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (191)
1 – 10 of 191
AVP
Tbio
Novelty: 0.00016475
Score: 0.979
Data Source: Reactome,STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.968
Data Source: STRINGDB
GNRHR
Tclin
Family: GPCR
Novelty: 0.00203671
Score: 0.95
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.944
Data Source: STRINGDB
EDN2
Tbio
Novelty: 0.00203492
Score: 0.944
Data Source: STRINGDB
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
Score: 0.944
Data Source: STRINGDB
FFAR1
Tchem
Family: GPCR
Novelty: 0.00271782
Score: 0.942
Data Source: STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.938
Data Source: STRINGDB
EDN3
Tbio
Novelty: 0.00116752
Score: 0.938
Data Source: STRINGDB
GNG4
Tbio
Novelty: 0.14371438
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  126.31

PubMed score by year
PubTator Score  43.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer