P2RY1
P2Y purinoceptor 1
Protein Summary
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
- ENST00000305097
- ENSP00000304767
- ENSG00000169860
- P2Y1
- SARCC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
biological process | 0.98 | ||
ligand (chemical) | 0.85 | ||
transcription factor binding site profile | 0.67 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.95 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 365 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.95 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 365 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 401
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2