Tchem P2RY1 P2Y purinoceptor 1

Protein Summary

Description

Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P47900
• P2Y1

Gene Name

• P2RY1

Ensembl ID

• ENST00000305097
• ENSP00000304767
• ENSG00000169860

Symbol

• P2Y1
• SARCC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.98
ligand (chemical)	0.85
transcription factor binding site profile	0.67
tissue sample	0.65

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.15   (req: < 5)

Gene RIFs: 83   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.15   (req: >= 5)

Gene RIFs: 83   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 401

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

adenosine triphosphate

P2RY1Tchem GPCR

AGONIST pEC50 : 6.3

suramin

P2RY1Tchem GPCR

pIC50 : 6.52

Active Ligands (401)

Explore Active Ligands

1 – 10 of 401

ADP

P2RY1Tchem GPCR

pKd : 6.49

2MeSATP

P2RY1Tchem GPCR

-log(-) : 7.7

PPADS

P2RY1Tchem GPCR

pIC50 : 6.62

ATPgammaS

P2RY1Tchem GPCR

: 7.4

2MeSADP

P2RY1Tchem GPCR

pKd : 7.3

ADP&beta;S

P2RY1Tchem GPCR

-log(-) : 8.6

2,2'-pyridylisatogen tosylate

P2RY1Tchem GPCR

pIC50 : 6.85

CHEMBL2381908

P2RY1Tchem GPCR

pKi : 7.52

CHEMBL3092631

P2RY1Tchem GPCR

pKi : 7.8

CHEMBL2381898

P2RY1Tchem GPCR

pKi : 7.77

Protein-Protein Interactions (237)

Explore Interacting Targets

1 – 10 of 237

• See Interactions on String-DB

MIB2

Tbio

Family:  Enzyme

Novelty:  0.044378

p_int:  0.999999426

p_ni:  5.72e-7

p_wrong:  1e-9

Score:  0.197

Data Source:  BioPlex,STRINGDB

ATP11C

Tbio

Family:  Transporter

Novelty:  0.05441047

p_int:  0.988197241

p_ni:  0.011802759

Score:  0.179

Data Source:  BioPlex,STRINGDB

CMIP

Tbio

Novelty:  0.0076969

p_int:  0.914885122

p_ni:  2.13e-7

p_wrong:  0.085114666

Score:  0.517

Data Source:  BioPlex,STRINGDB

SLC19A2

Tbio

Family:  Transporter

Novelty:  0.00761796

p_int:  0.913468483

p_ni:  0.08646616

p_wrong:  0.000065358

Score:  0.186

Data Source:  BioPlex,STRINGDB

OSBPL8

Tbio

Novelty:  0.06812531

p_int:  0.82775373

p_ni:  0.17224627

Score:  0.158

Data Source:  BioPlex,STRINGDB

GPM6A

Tbio

Novelty:  0.04123799

p_int:  0.770459572

p_ni:  0.017711648

p_wrong:  0.211828779

Score:  0.169

Data Source:  BioPlex,STRINGDB

F2

Tclin

Family:  Enzyme

Novelty:  0.00004833

Score:  0.943

Data Source:  STRINGDB

TBXA2R

Tclin

Family:  GPCR

Novelty:  0.00571066

Score:  0.943

Data Source:  STRINGDB

GRM5

Tchem

Family:  GPCR

Novelty:  0.00062552

Score:  0.939

Data Source:  STRINGDB

KNG1

Tbio

Novelty:  0.00007684

Score:  0.932

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (12)

KEGG (4)

WikiPathways (2)

ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (52)

Functions (9)

Components (12)

Processes (31)

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1 – 9 of 9

GO Term	Evidence	Assigned by
ADP-activated adenosine receptor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP-activated adenosine receptor activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
G protein-coupled purinergic nucleotide receptor activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
scaffold protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
A1 adenosine receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl
ADP binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		1.4

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		1.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Blood coagulation
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hemostasis
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	purinergic receptor P2Y1	VGNC:12119	470970
Macaque	purinergic receptor P2Y1		708507
Mouse	purinergic receptor P2Y, G-protein coupled 1	MGI:105049	18441
Rat	purinergic receptor P2Y1	RGD:3242	25265
Dog	purinergic receptor P2Y1	VGNC:44213	449621

Species	Name	OMA	EggNOG	Inparanoid
Chimp	purinergic receptor P2Y1
Macaque	purinergic receptor P2Y1
Mouse	purinergic receptor P2Y, G-protein coupled 1
Rat	purinergic receptor P2Y1
Dog	purinergic receptor P2Y1

Publication Statistics

PubMed Score 476.15

PubMed score by year

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PubTator Score 408.61

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Patents

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Related Publications

Text Mined References (106)

GeneRif Annotations (83)

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PMID	Year	Title