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Tchem
HTR5A
5-hydroxytryptamine receptor 5A

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287907
  • ENSP00000287907
  • ENSG00000157219
  • ENST00000650536
  • ENSP00000497571

Symbol
  • 5-HT5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.8
gene perturbation
0.59
protein domain
0.58
cell type or tissue
0.52
cellular component
0.52


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.56   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.56   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 5A
VGNC:8691
463837
Macaque
5-hydroxytryptamine receptor 5A
716134
Mouse
MGI:96283
15563
Rat
RGD:2851
25689
Dog
5-hydroxytryptamine receptor 5A
VGNC:41832
482814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 5A
Macaque
5-hydroxytryptamine receptor 5A
Mouse
Rat
Dog
5-hydroxytryptamine receptor 5A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47898-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (423)
1 – 10 of 423
GPR37
Tbio
Family:  GPCR
Novelty:  0.02193644
Score:  0.969
Data Source:  STRINGDB
MCHR1
Tchem
Family:  GPCR
Novelty:  0.00295097
Score:  0.955
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.95
Data Source:  STRINGDB
OXGR1
Tchem
Family:  GPCR
Novelty:  0.03623646
Score:  0.948
Data Source:  STRINGDB
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.947
Data Source:  STRINGDB
HTR1E
Tchem
Family:  GPCR
Novelty:  0.02160816
Score:  0.945
Data Source:  STRINGDB
GRM3
Tchem
Family:  GPCR
Novelty:  0.00340947
Score:  0.943
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.942
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.941
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  55.56

PubMed score by year
PubTator Score  75.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer