Protein Classes
Protein Summary
Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
- ENST00000306125
- ENSP00000307567
- ENSG00000172053
- ENST00000414533
- ENSP00000390015
- GLNRS
- MSCCA
- PRO2195
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
interacting protein | 0.97 | ||
histone modification site profile | 0.92 | ||
molecular function | 0.9 | ||
kinase perturbation | 0.84 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.26 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.26 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body fat distribution | 2 | 1 | 4 | 61.8 | |||||
chronotype measurement | 1 | 1 | 0 | 1.1 | 60.8 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body fat distribution | 4 | 61.8 | |||||
chronotype measurement | 0 | 1.1 | 60.8 | ||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (8)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial tRNA aminoacylation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
Mitochondrial tRNA aminoacylation | ||||
Gene Ontology Terms (16)
Functions (4)
Components (5)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (281)
1 – 10 of 281
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999747247
p_ni: 0.000252753
Score: 0.999
Data Source: BioPlex,STRINGDB
KARS
Family: Enzyme
Novelty: 0.00386511
p_int: 0.996556499
p_ni: 0.003443501
Score: 0.999
Data Source: BioPlex,STRINGDB
EEF1E1
Novelty: 0.06216577
p_int: 0.995857055
p_ni: 0.004142945
Score: 0.993
Data Source: BioPlex,STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03283387
p_int: 0.995715384
p_ni: 0.004284616
Score: 0.997
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.994490591
p_ni: 0.005509409
Score: 0.999
Data Source: BioPlex,STRINGDB
PPM1A
Family: Enzyme
Novelty: 0.01464968
p_int: 0.990350133
p_ni: 0.009649867
Score: 0.16
Data Source: BioPlex,STRINGDB
DARS
Family: Enzyme
Novelty: 0.01101888
p_int: 0.989075671
p_ni: 0.010924329
Score: 0.997
Data Source: BioPlex,STRINGDB
LARS
Family: Enzyme
Novelty: 0.00361711
p_int: 0.979651138
p_ni: 0.020348862
Score: 0.999
Data Source: BioPlex,STRINGDB
EPRS
Family: Enzyme
Novelty: 0.00084896
p_int: 0.975918754
p_ni: 0.024081246
Score: 0.998
Data Source: BioPlex,STRINGDB
IARS
Family: Enzyme
Novelty: 0.00539046
p_int: 0.962799845
p_ni: 0.037200155
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 46.26
PubMed score by year
PubTator Score 58.48
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: