Tchem QARS Glutamine--tRNA ligase

Protein Classes

PANTHER Classes

Protein / Ligase / Glutamine--trna Ligase

DTO Classes

Protein / Enzyme / Ligase / Glutamine--trna Ligase

Protein Summary

Description

Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P47897
• B4DWJ2

Gene Name

• QARS

Ensembl ID

• ENST00000306125
• ENSP00000307567
• ENSG00000172053
• ENST00000414533
• ENSP00000390015

Symbol

• GLNRS
• MSCCA
• PRO2195

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
interacting protein	0.97
histone modification site profile	0.92
molecular function	0.9
kinase perturbation	0.84

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.26   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.26   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

glutaminyl adenylate analogue

QARSTchem Enzyme

Ki : 6.07

GWAS Traits (29)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1	2	2		85.8
eosinophil count	EFO_0004842	1	1	1		81
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		75.1
unipolar depression	EFO_0003761	3	2	2	1	73.8
body fat distribution	EFO_0004341	2	1	4		70.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2		85.8
eosinophil count	EFO_0004842	1		81
BMI-adjusted waist-hip ratio	EFO_0007788	1		75.1
unipolar depression	EFO_0003761	2	1	73.8
body fat distribution	EFO_0004341	4		70.5

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthetase	VGNC:2529	743625
Macaque	glutaminyl-tRNA synthetase		708111
Mouse	glutaminyl-tRNA synthetase	MGI:1915851	97541
Rat	glutamine--tRNA ligase-like	RGD:6494601	100911132
Dog	glutaminyl-tRNA synthetase	VGNC:45230	476628

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthetase
Macaque	glutaminyl-tRNA synthetase
Mouse	glutaminyl-tRNA synthetase
Rat	glutamine--tRNA ligase-like
Dog	glutaminyl-tRNA synthetase

Protein Structure (4 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47897-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (13)

Reactome (8)

KEGG (2)

PathwayCommons (3)

Cytosolic tRNA aminoacylation (R-HSA-379716)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial tRNA aminoacylation	21 targets	R-HSA-379726

Name	Explore in Pharos	Explore in Source
Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial tRNA aminoacylation	21 targets	R-HSA-379726

Gene Ontology Terms (16)

Functions (4)

Components (5)

Processes (7)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
glutamine-tRNA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	CAFA
protein kinase inhibitor activity	Inferred from Mutant Phenotype (IMP)	CAFA
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (281)

Explore Interacting Targets

1 – 10 of 281

• See Interactions on String-DB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.999747247

p_ni:  0.000252753

Score:  0.999

Data Source:  BioPlex,STRINGDB

KARS

Tchem

Family:  Enzyme

Novelty:  0.00386511

p_int:  0.996556499

p_ni:  0.003443501

Score:  0.999

Data Source:  BioPlex,STRINGDB

EEF1E1

Tbio

Novelty:  0.06216577

p_int:  0.995857055

p_ni:  0.004142945

Score:  0.993

Data Source:  BioPlex,STRINGDB

AIMP2

Tchem

Family:  Enzyme

Novelty:  0.03283387

p_int:  0.995715384

p_ni:  0.004284616

Score:  0.997

Data Source:  BioPlex,STRINGDB

AIMP1

Tbio

Family:  Enzyme

Novelty:  0.00743447

p_int:  0.994490591

p_ni:  0.005509409

Score:  0.999

Data Source:  BioPlex,STRINGDB

PPM1A

Tchem

Family:  Enzyme

Novelty:  0.01464968

p_int:  0.990350133

p_ni:  0.009649867

Score:  0.16

Data Source:  BioPlex,STRINGDB

DARS

Tbio

Family:  Enzyme

Novelty:  0.01101888

p_int:  0.989075671

p_ni:  0.010924329

Score:  0.997

Data Source:  BioPlex,STRINGDB

LARS

Tchem

Family:  Enzyme

Novelty:  0.00361711

p_int:  0.979651138

p_ni:  0.020348862

Score:  0.999

Data Source:  BioPlex,STRINGDB

EPRS

Tchem

Family:  Enzyme

Novelty:  0.00084896

p_int:  0.975918754

p_ni:  0.024081246

Score:  0.998

Data Source:  BioPlex,STRINGDB

IARS

Tchem

Family:  Enzyme

Novelty:  0.00539046

p_int:  0.962799845

p_ni:  0.037200155

Score:  0.999

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  47.26

PubMed score by year

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PubTator Score  58.48

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Epilepsy

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat distribution
chronotype measurement
cognitive function measurement
coronary artery disease
creatinine measurement
endometriosis
eosinophil count