Tchem QARS Glutamine--tRNA ligase

Protein Summary

Description

Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P47897
• B4DWJ2

Gene Name

• QARS

Ensembl ID

• ENST00000306125
• ENSP00000307567
• ENSG00000172053
• ENST00000414533
• ENSP00000390015

Symbol

• GLNRS
• MSCCA
• PRO2195

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
interacting protein	0.97
histone modification site profile	0.92
molecular function	0.9
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Ligase / Glutamine--trna Ligase

DTO Classes

Protein / Enzyme / Ligase / Glutamine--trna Ligase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.26   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.26   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

glutaminyl adenylate analogue

QARSTchem Enzyme

pKi : 6.07

Protein-Protein Interactions (281)

Explore Interacting Targets

1 – 10 of 281

• See Interactions on String-DB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.999747247

p_ni:  0.000252753

Score:  0.999

Data Source:  BioPlex,STRINGDB

KARS

Tchem

Family:  Enzyme

Novelty:  0.00386511

p_int:  0.996556499

p_ni:  0.003443501

Score:  0.999

Data Source:  BioPlex,STRINGDB

EEF1E1

Tbio

Novelty:  0.06216577

p_int:  0.995857055

p_ni:  0.004142945

Score:  0.993

Data Source:  BioPlex,STRINGDB

AIMP2

Tchem

Family:  Enzyme

Novelty:  0.03283387

p_int:  0.995715384

p_ni:  0.004284616

Score:  0.997

Data Source:  BioPlex,STRINGDB

AIMP1

Tbio

Family:  Enzyme

Novelty:  0.00743447

p_int:  0.994490591

p_ni:  0.005509409

Score:  0.999

Data Source:  BioPlex,STRINGDB

PPM1A

Tchem

Family:  Enzyme

Novelty:  0.01464968

p_int:  0.990350133

p_ni:  0.009649867

Score:  0.16

Data Source:  BioPlex,STRINGDB

DARS

Tbio

Family:  Enzyme

Novelty:  0.01101888

p_int:  0.989075671

p_ni:  0.010924329

Score:  0.997

Data Source:  BioPlex,STRINGDB

LARS

Tchem

Family:  Enzyme

Novelty:  0.00361711

p_int:  0.979651138

p_ni:  0.020348862

Score:  0.999

Data Source:  BioPlex,STRINGDB

EPRS

Tchem

Family:  Enzyme

Novelty:  0.00084896

p_int:  0.975918754

p_ni:  0.024081246

Score:  0.998

Data Source:  BioPlex,STRINGDB

IARS

Tchem

Family:  Enzyme

Novelty:  0.00539046

p_int:  0.962799845

p_ni:  0.037200155

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (8)

KEGG (2)

PathwayCommons (3)

Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial tRNA aminoacylation	21 targets	R-HSA-379726

Name	Explore in Pharos	Explore in Source
Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial tRNA aminoacylation	21 targets	R-HSA-379726

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (4)

Components (5)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
glutamine-tRNA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	CAFA
protein kinase inhibitor activity	Inferred from Mutant Phenotype (IMP)	CAFA
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (29)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 29

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1	2	2		85.8
eosinophil count	EFO_0004842	1	1	1		81
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		75.1
unipolar depression	EFO_0003761	3	2	2	1	73.8
body fat distribution	EFO_0004341	2	1	4		70.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 29

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2		85.8
eosinophil count	EFO_0004842	1		81
BMI-adjusted waist-hip ratio	EFO_0007788	1		75.1
unipolar depression	EFO_0003761	2	1	73.8
body fat distribution	EFO_0004341	4		70.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Epilepsy

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat distribution
chronotype measurement
cognitive function measurement
coronary artery disease
creatinine measurement
endometriosis
eosinophil count

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthetase	VGNC:2529	743625
Macaque	glutaminyl-tRNA synthetase		708111
Mouse	glutaminyl-tRNA synthetase	MGI:1915851	97541
Rat	glutamine--tRNA ligase-like	RGD:6494601	100911132
Dog	glutaminyl-tRNA synthetase	VGNC:45230	476628

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutaminyl-tRNA synthetase
Macaque	glutaminyl-tRNA synthetase
Mouse	glutaminyl-tRNA synthetase
Rat	glutamine--tRNA ligase-like
Dog	glutaminyl-tRNA synthetase

Publication Statistics

PubMed Score 47.26

PubMed score by year

Reset Zoom

PubTator Score 58.48

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (38)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title