Protein Summary
Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
- ENST00000306125
- ENSP00000307567
- ENSG00000172053
- ENST00000414533
- ENSP00000390015
- GLNRS
- MSCCA
- PRO2195
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
interacting protein | 0.97 | ||
histone modification site profile | 0.92 | ||
molecular function | 0.9 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.26 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.26 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (281)
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999747247
p_ni: 0.000252753
Score: 0.999
Data Source: BioPlex,STRINGDB
KARS
Family: Enzyme
Novelty: 0.00386511
p_int: 0.996556499
p_ni: 0.003443501
Score: 0.999
Data Source: BioPlex,STRINGDB
EEF1E1
Novelty: 0.06216577
p_int: 0.995857055
p_ni: 0.004142945
Score: 0.993
Data Source: BioPlex,STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03283387
p_int: 0.995715384
p_ni: 0.004284616
Score: 0.997
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.994490591
p_ni: 0.005509409
Score: 0.999
Data Source: BioPlex,STRINGDB
PPM1A
Family: Enzyme
Novelty: 0.01464968
p_int: 0.990350133
p_ni: 0.009649867
Score: 0.16
Data Source: BioPlex,STRINGDB
DARS
Family: Enzyme
Novelty: 0.01101888
p_int: 0.989075671
p_ni: 0.010924329
Score: 0.997
Data Source: BioPlex,STRINGDB
LARS
Family: Enzyme
Novelty: 0.00361711
p_int: 0.979651138
p_ni: 0.020348862
Score: 0.999
Data Source: BioPlex,STRINGDB
EPRS
Family: Enzyme
Novelty: 0.00084896
p_int: 0.975918754
p_ni: 0.024081246
Score: 0.998
Data Source: BioPlex,STRINGDB
IARS
Family: Enzyme
Novelty: 0.00539046
p_int: 0.962799845
p_ni: 0.037200155
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial tRNA aminoacylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
Mitochondrial tRNA aminoacylation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (29)
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 2 | 2 | 85.8 | |||||
eosinophil count | 1 | 1 | 1 | 81 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 75.1 | |||||
3 | 2 | 2 | 1 | 73.8 | |||||
body fat distribution | 2 | 1 | 4 | 70.5 | |||||
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
HbA1c measurement | 2 | 85.8 | |||||
eosinophil count | 1 | 81 | |||||
BMI-adjusted waist-hip ratio | 1 | 75.1 | |||||
2 | 1 | 73.8 | |||||
body fat distribution | 4 | 70.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glutaminyl-tRNA synthetase | VGNC:2529 | 743625 | |||||
Macaque | glutaminyl-tRNA synthetase | 708111 | ||||||
Mouse | MGI:1915851 | 97541 | ||||||
Rat | RGD:6494601 | 100911132 | ||||||
Dog | glutaminyl-tRNA synthetase | VGNC:45230 | 476628 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glutaminyl-tRNA synthetase | |||||
Macaque | glutaminyl-tRNA synthetase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutaminyl-tRNA synthetase | |||||
Publication Statistics
PubMed Score 47.26
PubMed score by year
PubTator Score 58.48
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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