Tclin SCTR Secretin receptor

Protein Summary

Description

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P47872
• Q12961
• Q13213
• Q53T00
• SCT-R

Gene Name

• SCTR

Ensembl ID

• ENST00000019103
• ENSP00000019103
• ENSG00000080293

Symbol

• SR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue	0.58
gene perturbation	0.57
phenotype	0.52
cell type or tissue	0.51

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Glucagon Receptor / Secretin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.95   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.95   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1