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Tclin
SCTR
Secretin receptor

Protein Summary
Description
This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000019103
  • ENSP00000019103
  • ENSG00000080293

Symbol
  • SR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue
0.58
gene perturbation
0.57
phenotype
0.52
cell type or tissue
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.52   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.52   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
secretin human
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
1
1.1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
47.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretin receptor
VGNC:2810
459576
Macaque
secretin receptor
695182
Mouse
MGI:2441720
319229
Rat
RGD:621342
81779
Dog
secretin receptor
VGNC:45934
483883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretin receptor
Macaque
secretin receptor
Mouse
Rat
Dog
secretin receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47872-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Protein-Protein Interactions (140)
1 – 10 of 140
SCT
Tbio
Novelty: 0.00070278
Score: 0.992
Data Source: Reactome,STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.976
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.962
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.96
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.956
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.954
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.953
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.953
Data Source: STRINGDB
GHRH
Tbio
Novelty: 0.00058152
Score: 0.948
Data Source: STRINGDB
PTHLH
Tbio
Novelty: 0.00050137
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.52

PubMed score by year
PubTator Score  96.68

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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