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Tclin
GCGR
Glucagon receptor

Protein Summary
Description
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400723
  • ENSP00000383558
  • ENSG00000215644

Symbol
  • GGR
  • GL-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.64
PubMedID
0.61
molecular function
0.6
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.45   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.45   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 575
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
glucagon
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
54.2
hemoglobin measurement
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
54.2
hemoglobin measurement
1
48.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucagon receptor
VGNC:9294
468357
Macaque
glucagon receptor
714542
Mouse
MGI:99572
14527
Rat
RGD:2669
24953
Dog
glucagon receptor
VGNC:41144
483368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucagon receptor
Macaque
glucagon receptor
Mouse
Rat
Dog
glucagon receptor
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47871-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (286)
1 – 10 of 286
GCG
Tchem
Novelty: 0.00004879
Score: 0.995
Data Source: Reactome,STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.966
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.964
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.96
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.956
Data Source: STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.952
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.95
Data Source: STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.94
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.939
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  230.45

PubMed score by year
PubTator Score  254.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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