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Tclin
GABRB2
Gamma-aminobutyric acid receptor subunit beta-2

Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274547
  • ENSP00000274547
  • ENSG00000145864
  • ENST00000353437
  • ENSP00000274546
  • ENST00000393959
  • ENSP00000377531
  • ENST00000520240
  • ENSP00000429320
  • ENST00000612710
  • ENSP00000480066

Symbol
  • ICEE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
co-expressed gene
0.96
molecular function
0.88
protein domain
0.85
chemical
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.99   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.99   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 37
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (37)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
topiramate
Rendered image for topiramate
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
p_int:  0.999999792
p_ni:  8e-9
p_wrong:  2e-7
Score:  0.916
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF25
Tbio
Novelty:  0.02782136
p_int:  0.94887039
p_ni:  0.021891424
p_wrong:  0.029238186
Score:  0.523
Data Source:  BioPlex,STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.989
Data Source:  Reactome,STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.988
Data Source:  Reactome,STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.98
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.976
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.97
Data Source:  STRINGDB
GABRA2
Tclin
Family:  IC
Novelty:  0.00663529
Score:  0.963
Data Source:  STRINGDB
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
Score:  0.961
Data Source:  STRINGDB
GABRG3
Tclin
Family:  IC
Novelty:  0.0420649
Score:  0.94
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
49.5
mathematical ability
1
1
1
39.6
self reported educational attainment
1
1
1
15.8
multisite chronic pain
1
1
1
14.2
1
1
0
6.6
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
49.5
mathematical ability
1
39.6
self reported educational attainment
1
15.8
multisite chronic pain
1
14.2
0
6.6
3.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta2 subunit
VGNC:8620
462240
Macaque
gamma-aminobutyric acid type A receptor beta2 subunit
696767
Mouse
MGI:95620
14401
Rat
RGD:2650
25451
Dog
gamma-aminobutyric acid type A receptor beta2 subunit
VGNC:41059
489146
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta2 subunit
Macaque
gamma-aminobutyric acid type A receptor beta2 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor beta2 subunit
Publication Statistics
PubMed Score 53.99
PubMed score by year
PubTator Score 31.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title