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Tbio
GPR12
G-protein coupled receptor 12

Protein Summary
Description
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381436
  • ENSP00000370844
  • ENSG00000132975
  • ENST00000405846
  • ENSP00000384932

Symbol
  • GPCR12
  • GPCR21
  • PPP1R84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
microRNA
0.78
cell type or tissue
0.76
molecular function
0.63
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0