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Tbio
CAPZB
F-actin-capping protein subunit beta

Protein Summary
Description
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264202
  • ENSP00000264202
  • ENSG00000077549
  • ENST00000375142
  • ENSP00000364284

Symbol
  • CAPB
  • CAPZ
  • CAPPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
hub protein
0.9
transcription factor perturbation
0.88
virus perturbation
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.2   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.2   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
92.2
urinary metabolite measurement
1
1
1
77.7
hormone measurement
1
1
3
73.6
platelet crit
2
2
2
72.4
viral load
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
92.2
urinary metabolite measurement
1
77.7
hormone measurement
3
73.6
platelet crit
2
72.4
viral load
1
68.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit beta
VGNC:11304
100612860
Macaque
capping actin protein of muscle Z-line beta subunit
100429776
Mouse
MGI:104652
12345
Rat
RGD:1359099
298584
Dog
capping actin protein of muscle Z-line subunit beta
VGNC:52114
478209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit beta
Macaque
capping actin protein of muscle Z-line beta subunit
Mouse
Rat
Dog
capping actin protein of muscle Z-line subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (317)
1 – 10 of 317
RCSD1
Tbio
Novelty:  0.11360488
p_int:  0.999748504
p_ni:  0.000251496
Score:  0.86
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999335175
p_ni:  0.000664825
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PLEKHO2
Tdark
Novelty:  0.48296621
p_int:  0.999064342
p_ni:  0.000935658
Score:  0.836
Data Source:  BioPlex,STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.992006143
p_ni:  0.007993857
Score:  0.752
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.989395162
p_ni:  0.010604838
Score:  0.84
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.954577388
p_ni:  0.045422612
Score:  0.974
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.82746635
p_ni:  0.17253365
Score:  0.993
Data Source:  BioPlex,STRINGDB
WASHC1
Tbio
Novelty:  0.09242196
p_int:  0.784347297
p_ni:  0.215652703
Score:  0.913
Data Source:  BioPlex,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.775027785
p_ni:  0.224972215
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.75089902
p_ni:  0.24910098
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  30.20

PubMed score by year
PubTator Score  31.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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