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Tbio
CAPZA2
F-actin-capping protein subunit alpha-2

Protein Summary
Description
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361183
  • ENSP00000354947
  • ENSG00000198898

Symbol
  • CAPZ
  • CAPPA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.9
disease perturbation
0.74
cell type or tissue
0.69
tissue
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
92.8
platelet count
2
2
2
90.9
platelet crit
2
2
2
75.7
triglyceride measurement
4
2
4
70.4
sex hormone-binding globulin measurement
4
2
4
69.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.8
platelet count
2
90.9
platelet crit
2
75.7
triglyceride measurement
4
70.4
sex hormone-binding globulin measurement
4
69.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 2
VGNC:7354
736736
Macaque
capping actin protein of muscle Z-line alpha subunit 2
704662
Mouse
MGI:106222
12343
Rat
RGD:1549770
493810
Dog
capping actin protein of muscle Z-line subunit alpha 2
VGNC:38711
503863
Species
Name
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 2
Macaque
capping actin protein of muscle Z-line alpha subunit 2
Mouse
Rat
Dog
capping actin protein of muscle Z-line subunit alpha 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47755-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Advanced glycosylation endproduct receptor signaling
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (252)
1 – 10 of 252
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  1
Score:  0.675
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  1
Score:  0.482
Data Source:  BioPlex,STRINGDB
CARMIL2
Tbio
Novelty:  0.08149323
p_int:  1
Score:  0.454
Data Source:  BioPlex,STRINGDB
PLEKHO2
Tdark
Novelty:  0.48296621
p_int:  1
Score:  0.291
Data Source:  BioPlex,STRINGDB
KIAA1211
Tdark
Novelty:  0.83445472
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
WASHC2A
Tdark
Novelty:  1.4430096
p_int:  0.999999996
p_ni:  4e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
WASH3P
Tbio
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  2e-9
Data Source:  BioPlex
CARMIL1
Tbio
Novelty:  0.04162135
p_int:  0.999999992
p_ni:  7e-9
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
WASHC2C
Tbio
Novelty:  0.09738237
p_int:  0.999999986
p_ni:  1e-9
p_wrong:  1.3e-8
Score:  0.787
Data Source:  BioPlex,STRINGDB
WASHC4
Tdark
Novelty:  0.05930527
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.401
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.70

PubMed score by year
PubTator Score  27.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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