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Tbio
RAP1GAP
Rap1 GTPase-activating protein 1

Protein Summary
Description
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374765
  • ENSP00000363897
  • ENSG00000076864
  • ENST00000495204
  • ENSP00000434033
  • ENST00000542643
  • ENSP00000441661

Symbol
  • KIAA0474
  • RAP1GA1
  • RAPGAP
  • RAP1GA1
  • RAP1GAP1
  • RAP1GAPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
molecular function
0.79
transcription factor
0.77
small molecule perturbation
0.68
hub protein
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.06   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.06   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
89.3
C-reactive protein measurement
1
1
1
69.7
reticulocyte count
4
2
4
66.9
alkaline phosphatase measurement
1
1
1
47.8
abdominal aortic calcification measurement
1
1
0
5.5
34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
89.3
C-reactive protein measurement
1
69.7
reticulocyte count
4
66.9
alkaline phosphatase measurement
1
47.8
abdominal aortic calcification measurement
0
5.5
34
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAP1 GTPase activating protein
VGNC:6973
456601
Macaque
RAP1 GTPase activating protein
717830
Mouse
MGI:109338
110351
Rat
RGD:1309908
313644
Horse
RAP1 GTPase activating protein
VGNC:50749
100071716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAP1 GTPase activating protein
Macaque
RAP1 GTPase activating protein
Mouse
Rat
Horse
RAP1 GTPase activating protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47736-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (117)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Immune System
Reactome
RET signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Developmental Biology
Immune System
RET signaling
Protein-Protein Interactions (83)
1 – 10 of 83
GNAI3
Tbio
Novelty: 0.03484857
p_int: 0.99999641
p_ni: 2.5e-8
p_wrong: 0.000003565
Score: 0.529
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.995
Data Source: Reactome,STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.995
Data Source: Reactome,STRINGDB
RET
Tclin
Family: Kinase
Novelty: 0.00028324
Score: 0.948
Data Source: Reactome,STRINGDB
GFRA3
Tbio
Novelty: 0.10149548
Score: 0.903
Data Source: Reactome,STRINGDB
GFRA2
Tbio
Novelty: 0.06235436
Score: 0.903
Data Source: Reactome,STRINGDB
GFRA4
Tbio
Novelty: 0.17473076
Score: 0.902
Data Source: Reactome,STRINGDB
GFRA1
Tbio
Novelty: 0.00373994
Score: 0.902
Data Source: Reactome,STRINGDB
GDNF
Tbio
Novelty: 0.00036702
Score: 0.902
Data Source: Reactome,STRINGDB
PSPN
Tbio
Novelty: 0.02169895
Score: 0.9
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  80.06

PubMed score by year
PubTator Score  54.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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