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Tchem
PLA2G4A
Cytosolic phospholipase A2

Protein Summary
Description
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367466
  • ENSP00000356436
  • ENSG00000116711

Symbol
  • CPLA2
  • PLA2G4
  • GURDP
  • cPLA2
  • PLA2G4
  • cPLA2-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.99
metabolite
0.95
biological term
0.94
gene perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.87   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.87   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 159
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
37.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
37.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (79)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acyl chain remodeling of CL
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acyl chain remodeling of CL
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (169)
1 – 10 of 169
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.971
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.969
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.968
Data Source: Reactome,STRINGDB
MKNK1
Tchem
Family: Kinase
Novelty: 0.01445137
Score: 0.951
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.946
Data Source: STRINGDB
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.936
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.934
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.928
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.925
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.0587776
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  691.87

PubMed score by year
PubTator Score  707.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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