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Tbio
RABIF
Guanine nucleotide exchange factor MSS4

Protein Summary
Description
Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport. This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367262
  • ENSP00000356231
  • ENSG00000183155

Symbol
  • MSS4
  • RASGRF3
  • MSS4
  • RASGFR3
  • RASGRF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
kinase perturbation
0.84
histone modification site profile
0.81
transcription factor perturbation
0.68
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
p_int:  0.999999186
p_ni:  8.14e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
RAB3B
Tbio
Family:  Enzyme
Novelty:  0.02731183
p_int:  0.999798586
p_ni:  0.000201406
p_wrong:  8e-9
Score:  0.334
Data Source:  BioPlex,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999677725
p_ni:  0.00020413
p_wrong:  0.000118145
Score:  0.151
Data Source:  BioPlex,STRINGDB
RAB10
Tbio
Family:  Enzyme
Novelty:  0.00870713
p_int:  0.999483057
p_ni:  0.000516943
Score:  0.796
Data Source:  BioPlex,STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
p_int:  0.998295603
p_ni:  0.001704175
p_wrong:  2.21e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
p_int:  0.996519745
p_ni:  0.003480255
Score:  0.699
Data Source:  BioPlex,STRINGDB
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.994681482
p_ni:  0.005318512
p_wrong:  6e-9
Data Source:  BioPlex
SLC25A31
Tbio
Family:  Transporter
Novelty:  0.02122923
p_int:  0.993757004
p_ni:  8.6e-8
p_wrong:  0.00624291
Data Source:  BioPlex
VIPAS39
Tbio
Novelty:  0.02348642
p_int:  0.986329456
p_ni:  0.008989179
p_wrong:  0.004681365
Data Source:  BioPlex
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.976029409
p_ni:  0.02396174
p_wrong:  0.000008851
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (156)
Find Similar Targets
Items per page:
1 – 5 of 156
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
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WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
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WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
Name
Explore in Pharos
Explore in Source
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
75.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB interacting factor
VGNC:11813
457633
Mouse
MGI:2138605
98710
Rat
RGD:1359331
304807
Dog
RAB interacting factor
VGNC:45305
100855654
Horse
RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB interacting factor
Mouse
Rat
Dog
RAB interacting factor
Horse
RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797]
Publication Statistics
PubMed Score 4.39
PubMed score by year
PubTator Score 21.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title