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Tchem
GALR1
Galanin receptor type 1

Protein Summary
Description
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299727
  • ENSP00000299727
  • ENSG00000166573

Symbol
  • GALNR
  • GALNR1
  • GALNR
  • GALNR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.86
molecular function
0.67
cell type or tissue
0.62
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.37   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.37   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
1
1.3
54
body height
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1.3
54
body height
1
19.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galanin receptor 1
VGNC:5171
468586
Macaque
galanin receptor 1
697450
Mouse
MGI:1096364
14427
Rat
RGD:2656
50577
Dog
galanin receptor 1
VGNC:41100
483928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galanin receptor 1
Macaque
galanin receptor 1
Mouse
Rat
Dog
galanin receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P47211-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (246)
1 – 10 of 246
GAL
Tbio
Novelty: 0.0005132
Score: 0.997
Data Source: Reactome,STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.954
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.947
Data Source: STRINGDB
PPY
Tbio
Novelty: 0.00060933
Score: 0.932
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.927
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.923
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.923
Data Source: STRINGDB
PNOC
Tbio
Novelty: 0.00132014
Score: 0.923
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.921
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.37

PubMed score by year
PubTator Score  66.37

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer