Tbio STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Protein Summary

Description

Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:19167329). The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P46977
• B4DJ24
• E9PNQ1
• Q86XU9
• Q8TE35
• Q8WUB4
• Oligosaccharyl transferase subunit STT3A

Gene Name

• STT3A

Ensembl ID

• ENST00000392708
• ENSP00000376472
• ENSG00000134910
• ENST00000529196
• ENSP00000436962
• ENST00000531491
• ENSP00000432820
• ENST00000649491
• ENSP00000497336

Symbol

• ITM1
• TMC
• TMC
• ITM1
• STT3-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
interacting protein	0.82
transcription factor binding site profile	0.82
pathway	0.74
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit Stt3a

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit Stt3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.05   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.05   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0