Tbio GYG1 Glycogenin-1

Protein Summary

Description

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P46976
• D3DNH0
• D3DNH1
• D3DNH2
• Q6FHZ1
• Q9UNV0
• GN-1

Gene Name

• GYG1

Ensembl ID

• ENST00000296048
• ENSP00000296048
• ENSG00000163754
• ENST00000345003
• ENSP00000340736
• ENST00000484197
• ENSP00000420683

Symbol

• GYG
• GYG
• GSD15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.9
kinase perturbation	0.88
interacting protein	0.77
cell type or tissue	0.75

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (72)

Explore Interacting Targets

1 – 10 of 72

• See Interactions on String-DB

STBD1

Tbio

Novelty:  0.08362185

p_int:  0.999094721

p_ni:  0.000905279

Score:  0.933

Data Source:  BioPlex,STRINGDB

GYG2

Tbio

Family:  Enzyme

Novelty:  0.01520991

p_int:  0.998748705

p_ni:  0.001251295

Score:  0.968

Data Source:  BioPlex,STRINGDB

GBE1

Tbio

Family:  Enzyme

Novelty:  0.00233237

p_int:  0.998061973

p_ni:  0.001938027

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

AMY2A

Tclin

Family:  Enzyme

Novelty:  0.00132709

p_int:  0.983939488

p_ni:  0.016060512

Score:  0.218

Data Source:  BioPlex,STRINGDB

PRKAB2

Tchem

Family:  Enzyme

Novelty:  0.02815065

p_int:  0.959484162

p_ni:  0.040515838

Score:  0.799

Data Source:  BioPlex,STRINGDB

PPP1R3C

Tbio

Family:  Enzyme

Novelty:  0.01784199

p_int:  0.819621027

p_ni:  0.180378973

Score:  0.99

Data Source:  BioPlex,Reactome,STRINGDB

GYS1

Tchem

Family:  Enzyme

Novelty:  0.00721964

Score:  0.995

Data Source:  Reactome,STRINGDB

GYS2

Tbio

Family:  Enzyme

Novelty:  0.01522741

Score:  0.989

Data Source:  STRINGDB

AGL

Tbio

Novelty:  0.00166875

Score:  0.976

Data Source:  Reactome,STRINGDB

UGP2

Tbio

Family:  Enzyme

Novelty:  0.00760963

Score:  0.961

Data Source:  STRINGDB

Pathways (204)

Reactome (16)

KEGG (2)

UniProt (1)

WikiPathways (185)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Reactome	Diseases of metabolism	103 targets	R-HSA-5668914
Reactome	Glycogen breakdown (glycogenolysis)	15 targets	R-HSA-70221
Reactome	Glycogen metabolism	28 targets	R-HSA-8982491

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Diseases of metabolism	103 targets	R-HSA-5668914
Glycogen breakdown (glycogenolysis)	15 targets	R-HSA-70221
Glycogen metabolism	28 targets	R-HSA-8982491

Gene Ontology Terms (11)

Functions (3)

Components (6)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
glycogenin glucosyltransferase activity	Inferred from Experiment (EXP)	Reactome
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
birth weight	EFO_0004344	3	2	3		59.6
eosinophil count	EFO_0004842	2	1	2		54.4
mean reticulocyte volume	EFO_0010701	1	1	1		13.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
birth weight	EFO_0004344	3		59.6
eosinophil count	EFO_0004842	2		54.4
mean reticulocyte volume	EFO_0010701	1		13.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Glycogen biosynthesis
Glycogen storage disease
Glycoprotein
Manganese
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
eosinophil count
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
respiratory system phenotype

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glycogenin 1	VGNC:1834	460765
Macaque	glycogenin 1		712495
Mouse	glycogenin	MGI:1351614	27357
Rat	glycogenin 1	RGD:621785	81675
Dog	glycogenin 1	VGNC:41572	611614

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glycogenin 1
Macaque	glycogenin 1
Mouse	glycogenin
Rat	glycogenin 1
Dog	glycogenin 1

Publication Statistics

PubMed Score 59.71

PubMed score by year

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PubTator Score 54.28

PubTator score by year

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