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Tbio
GYG1
Glycogenin-1

Protein Summary
Description
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296048
  • ENSP00000296048
  • ENSG00000163754
  • ENST00000345003
  • ENSP00000340736
  • ENST00000484197
  • ENSP00000420683

Symbol
  • GYG
  • GYG
  • GSD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
kinase perturbation
0.88
interacting protein
0.77
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.1   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.1   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (204)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Protein-Protein Interactions (72)
1 – 10 of 72
STBD1
Tbio
Novelty: 0.12096774
p_int: 0.999094721
p_ni: 0.000905279
Score: 0.933
Data Source: BioPlex,STRINGDB
GYG2
Tbio
Family: Enzyme
Novelty: 0.01017368
p_int: 0.998748705
p_ni: 0.001251295
Score: 0.968
Data Source: BioPlex,STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00472598
p_int: 0.998061973
p_ni: 0.001938027
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
AMY2A
Tclin
Family: Enzyme
Novelty: 0.00110041
p_int: 0.983939488
p_ni: 0.016060512
Score: 0.218
Data Source: BioPlex,STRINGDB
PRKAB2
Tchem
Family: Enzyme
Novelty: 0.05936112
p_int: 0.959484162
p_ni: 0.040515838
Score: 0.799
Data Source: BioPlex,STRINGDB
PPP1R3C
Tbio
Family: Enzyme
Novelty: 0.01542439
p_int: 0.819621027
p_ni: 0.180378973
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
GYS1
Tchem
Family: Enzyme
Novelty: 0.0058053
Score: 0.995
Data Source: Reactome,STRINGDB
GYS2
Tbio
Family: Enzyme
Novelty: 0.02261199
Score: 0.989
Data Source: STRINGDB
AGL
Tbio
Novelty: 0.00236651
Score: 0.976
Data Source: Reactome,STRINGDB
UGP2
Tbio
Family: Enzyme
Novelty: 0.00283311
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.10

PubMed score by year
PubTator Score  54.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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