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Tbio
GYG1
Glycogenin-1

Protein Summary
Description
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296048
  • ENSP00000296048
  • ENSG00000163754
  • ENST00000345003
  • ENSP00000340736
  • ENST00000484197
  • ENSP00000420683

Symbol
  • GYG
  • GYG
  • GSD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
kinase perturbation
0.88
interacting protein
0.77
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (72)
1 – 10 of 72
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999094721
p_ni:  0.000905279
Score:  0.933
Data Source:  BioPlex,STRINGDB
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
p_int:  0.998748705
p_ni:  0.001251295
Score:  0.968
Data Source:  BioPlex,STRINGDB
GBE1
Tbio
Family:  Enzyme
Novelty:  0.00233237
p_int:  0.998061973
p_ni:  0.001938027
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
p_int:  0.983939488
p_ni:  0.016060512
Score:  0.218
Data Source:  BioPlex,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.959484162
p_ni:  0.040515838
Score:  0.799
Data Source:  BioPlex,STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
p_int:  0.819621027
p_ni:  0.180378973
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
Score:  0.995
Data Source:  Reactome,STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
Score:  0.989
Data Source:  STRINGDB
AGL
Tbio
Novelty:  0.00166875
Score:  0.976
Data Source:  Reactome,STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
Score:  0.961
Data Source:  STRINGDB
Pathways (204)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
2
3
59.6
eosinophil count
2
1
2
54.4
mean reticulocyte volume
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
59.6
eosinophil count
2
54.4
mean reticulocyte volume
1
13.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogenin 1
VGNC:1834
460765
Macaque
glycogenin 1
712495
Mouse
MGI:1351614
27357
Rat
RGD:621785
81675
Dog
glycogenin 1
VGNC:41572
611614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogenin 1
Macaque
glycogenin 1
Mouse
Rat
Dog
glycogenin 1
Publication Statistics
PubMed Score 59.71
PubMed score by year
PubTator Score 54.28
PubTator score by year