Protein Classes
Protein Summary
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
- ENST00000296048
- ENSP00000296048
- ENSG00000163754
- ENST00000345003
- ENSP00000340736
- ENST00000484197
- ENSP00000420683
- GYG
- GYG
- GSD15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.94 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
interacting protein | 0.77 | ||
cell type or tissue | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.1 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.1 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (204)
Reactome (16)
KEGG (2)
UniProt (1)
WikiPathways (185)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glycogen breakdown (glycogenolysis) | ||||
Reactome | Glycogen metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Glycogen breakdown (glycogenolysis) | ||||
Glycogen metabolism | ||||
Gene Ontology Terms (11)
Functions (3)
Components (6)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (72)
1 – 10 of 72
STBD1
Novelty: 0.12096774
p_int: 0.999094721
p_ni: 0.000905279
Score: 0.933
Data Source: BioPlex,STRINGDB
GYG2
Family: Enzyme
Novelty: 0.01017368
p_int: 0.998748705
p_ni: 0.001251295
Score: 0.968
Data Source: BioPlex,STRINGDB
GBE1
Family: Enzyme
Novelty: 0.00472598
p_int: 0.998061973
p_ni: 0.001938027
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
AMY2A
Family: Enzyme
Novelty: 0.00110041
p_int: 0.983939488
p_ni: 0.016060512
Score: 0.218
Data Source: BioPlex,STRINGDB
PRKAB2
Family: Enzyme
Novelty: 0.05936112
p_int: 0.959484162
p_ni: 0.040515838
Score: 0.799
Data Source: BioPlex,STRINGDB
PPP1R3C
Family: Enzyme
Novelty: 0.01542439
p_int: 0.819621027
p_ni: 0.180378973
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
GYS1
Family: Enzyme
Novelty: 0.0058053
Score: 0.995
Data Source: Reactome,STRINGDB
GYS2
Family: Enzyme
Novelty: 0.02261199
Score: 0.989
Data Source: STRINGDB
AGL
Novelty: 0.00236651
Score: 0.976
Data Source: Reactome,STRINGDB
UGP2
Family: Enzyme
Novelty: 0.00283311
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score 83.10
PubMed score by year
PubTator Score 54.28
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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