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Tbio
HAAO
3-hydroxyanthranilate 3,4-dioxygenase

Protein Summary
Description
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294973
  • ENSP00000294973
  • ENSG00000162882

Symbol
  • HAO
  • 3-HAO
  • VCRL1
  • h3HAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
biological process
0.76
histone modification site profile
0.69
tissue sample
0.68
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
KYNU
Tchem
Family:  Enzyme
Novelty:  0.01372383
Score:  0.998
Data Source:  STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
Score:  0.991
Data Source:  STRINGDB
KMO
Tchem
Family:  Enzyme
Novelty:  0.01469543
Score:  0.985
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.919
Data Source:  STRINGDB
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
Score:  0.889
Data Source:  STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
Score:  0.872
Data Source:  STRINGDB
NAPRT
Tchem
Family:  Enzyme
Novelty:  0.0307992
Score:  0.804
Data Source:  STRINGDB
KYAT1
Tbio
Family:  Enzyme
Novelty:  0.01232903
Score:  0.778
Data Source:  STRINGDB
AADAT
Tchem
Family:  Enzyme
Novelty:  0.00678753
Score:  0.768
Data Source:  STRINGDB
HGD
Tbio
Family:  Enzyme
Novelty:  0.01924565
Score:  0.758
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
MAOA
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
MAOB
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
TPH1
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
DDC
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
Pathways (53)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
81.1
white matter hyperintensity measurement
4
3
3
7.2
57.1
mean corpuscular volume
1
1
1
49.5
body mass index
1
1
1
38.2
platelet count
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
81.1
white matter hyperintensity measurement
3
7.2
57.1
mean corpuscular volume
1
49.5
body mass index
1
38.2
platelet count
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1349444
107766
Rat
RGD:71071
56823
Dog
3-hydroxyanthranilate 3,4-dioxygenase
VGNC:41580
611728
Horse
3-hydroxyanthranilate 3,4-dioxygenase
VGNC:18676
100053689
Cow
3-hydroxyanthranilate 3,4-dioxygenase
VGNC:29735
510602
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
3-hydroxyanthranilate 3,4-dioxygenase
Horse
3-hydroxyanthranilate 3,4-dioxygenase
Cow
3-hydroxyanthranilate 3,4-dioxygenase
Publication Statistics
PubMed Score 33.58
PubMed score by year
PubTator Score 109.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title