You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HAAO
3-hydroxyanthranilate 3,4-dioxygenase

Protein Summary
Description
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294973
  • ENSP00000294973
  • ENSG00000162882

Symbol
  • HAO
  • 3-HAO
  • VCRL1
  • h3HAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
biological process
0.76
histone modification site profile
0.69
tissue sample
0.68
transcription factor binding site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (53)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Protein-Protein Interactions (92)
1 – 10 of 92
KYNU
Tchem
Family: Enzyme
Novelty: 0.02414561
Score: 0.998
Data Source: STRINGDB
ACMSD
Tbio
Family: Enzyme
Novelty: 0.01978706
Score: 0.991
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.00558444
Score: 0.985
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00022628
Score: 0.919
Data Source: STRINGDB
TDO2
Tchem
Family: Enzyme
Novelty: 0.00123905
Score: 0.889
Data Source: STRINGDB
QPRT
Tbio
Family: Enzyme
Novelty: 0.00969466
Score: 0.872
Data Source: STRINGDB
NAPRT
Tbio
Family: Enzyme
Novelty: 0.05728379
Score: 0.804
Data Source: STRINGDB
KYAT1
Tbio
Family: Enzyme
Novelty: 0.01429382
Score: 0.778
Data Source: STRINGDB
AADAT
Tchem
Family: Enzyme
Novelty: 0.0054217
Score: 0.768
Data Source: STRINGDB
HGD
Tbio
Family: Enzyme
Novelty: 0.00213809
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.22

PubMed score by year
PubTator Score  109.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: