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Tbio
IQGAP1
Ras GTPase-activating-like protein IQGAP1

Protein Summary
Description
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268182
  • ENSP00000268182
  • ENSG00000140575

Symbol
  • KIAA0051
  • SAR1
  • p195
  • HUMORFA01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
molecular function
0.99
protein domain
0.99
transcription factor perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.38   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.38   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
95.5
Eczema
2
2
0
1.1
94.3
heel bone mineral density
2
2
2
92
lymphocyte count
3
2
3
90.6
balding measurement
1
1
1
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
95.5
Eczema
0
1.1
94.3
heel bone mineral density
2
92
lymphocyte count
3
90.6
balding measurement
1
90.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 1
VGNC:1929
467762
Macaque
IQ motif containing GTPase activating protein 1
709283
Mouse
MGI:1352757
29875
Rat
RGD:1311884
361598
Dog
IQ motif containing GTPase activating protein 1
VGNC:42081
479050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 1
Macaque
IQ motif containing GTPase activating protein 1
Mouse
Rat
Dog
IQ motif containing GTPase activating protein 1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (168)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (273)
1 – 10 of 273
MYL6
Tbio
Novelty: 0.00594485
p_int: 0.999964664
p_ni: 0.000035337
Score: 0.383
Data Source: BioPlex,STRINGDB
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.999938501
p_ni: 0.000061499
Score: 0.324
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.998961305
p_ni: 0.001038695
Score: 0.213
Data Source: BioPlex,STRINGDB
NAP1L5
Tbio
Novelty: 0.10378595
p_int: 0.995052348
p_ni: 0.004947652
Data Source: BioPlex
PARVA
Tbio
Novelty: 0.02736601
p_int: 0.989495824
p_ni: 0.010504176
Score: 0.271
Data Source: BioPlex,STRINGDB
MYL10
Tdark
Novelty: 0.01378575
p_int: 0.989102986
p_ni: 0.010897014
Score: 0.466
Data Source: BioPlex,STRINGDB
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
p_int: 0.986207705
p_ni: 0.013792295
Data Source: BioPlex
MYL3
Tbio
Novelty: 0.00493817
p_int: 0.985699718
p_ni: 0.014300281
Score: 0.322
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.95028768
p_ni: 0.04971232
Score: 0.336
Data Source: BioPlex,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.93932395
p_ni: 0.06067605
Data Source: BioPlex
Publication Statistics
PubMed Score  295.38

PubMed score by year
PubTator Score  208.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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