Tchem UTRN Utrophin

Protein Summary

Description

May play a role in anchoring the cytoskeleton to the plasma membrane. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P46939
• Q5SYY1
• Q5SZ57
• Q9UJ40

Gene Name

• UTRN

Ensembl ID

• ENST00000367545
• ENSP00000356515
• ENSG00000152818

Symbol

• DMDL
• DRP1
• DRP
• DMDL
• DRP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.97
microRNA	0.77
interacting protein	0.76
trait	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.04   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.04   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0