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Tbio
RPS10
40S ribosomal protein S10

Protein Summary
Description
Component of the 40S ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside di ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326199
  • ENSP00000347271
  • ENSG00000124614
  • ENST00000464218
  • ENSP00000494440
  • ENST00000467531
  • ENSP00000494190
  • ENST00000621356
  • ENSP00000481646
  • ENST00000648437
  • ENSP00000497917

Symbol
  • S10
  • DBA9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
hub protein
0.82
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (392)
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.995858974
p_ni:  0.004141026
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.978338925
p_ni:  0.021661075
Score:  0.318
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.871640497
p_ni:  0.128359503
Score:  0.248
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.854723493
p_ni:  0.145276507
Score:  0.267
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.850542922
p_ni:  0.149457078
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.7779035
p_ni:  0.2220965
Data Source:  BioPlex
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.768779372
p_ni:  0.231220628
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.761928233
p_ni:  0.238071767
Score:  0.999
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.754246717
p_ni:  0.245753283
Score:  0.542
Data Source:  BioPlex,STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
87.5
BMI-adjusted waist circumference
2
2
3
86.4
appendicular lean mass
3
2
3
86.3
waist-hip ratio
2
1
2
82.9
waist circumference
1
1
1
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
87.5
BMI-adjusted waist circumference
3
86.4
appendicular lean mass
3
86.3
waist-hip ratio
2
82.9
waist circumference
1
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S10
718606
Mouse
MGI:1914347
67097
Rat
RGD:2323006
100363439
Dog
ribosomal protein S10
474877
Horse
ribosomal protein S10
100062360
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S10
Mouse
Rat
Dog
ribosomal protein S10
Horse
ribosomal protein S10
Publication Statistics
PubMed Score 86.85
PubMed score by year
PubTator Score 104.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title