RPS10
40S ribosomal protein S10
Protein Summary
Component of the 40S ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside di ...more
- ENST00000326199
- ENSP00000347271
- ENSG00000124614
- ENST00000464218
- ENSP00000494440
- ENST00000467531
- ENSP00000494190
- ENST00000621356
- ENSP00000481646
- ENST00000648437
- ENSP00000497917
- S10
- DBA9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
hub protein | 0.82 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.85 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 208 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.85 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 208 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (392)
RPS2
Novelty: 0.00412313
p_int: 0.995858974
p_ni: 0.004141026
Score: 0.999
Data Source: BioPlex,STRINGDB
RRS1
Novelty: 0.01643671
p_int: 0.978338925
p_ni: 0.021661075
Score: 0.318
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.871640497
p_ni: 0.128359503
Score: 0.248
Data Source: BioPlex,STRINGDB
HIST1H1E
Novelty: 0.01125284
p_int: 0.854723493
p_ni: 0.145276507
Score: 0.267
Data Source: BioPlex,STRINGDB
RPS16
Novelty: 0.00261983
p_int: 0.761928233
p_ni: 0.238071767
Score: 0.999
Data Source: BioPlex,STRINGDB
HIST1H1T
Novelty: 0.01039464
p_int: 0.754246717
p_ni: 0.245753283
Score: 0.542
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (39)
Reactome (36)
KEGG (1)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 87.5 | |||||
BMI-adjusted waist circumference | 2 | 2 | 3 | 86.4 | |||||
appendicular lean mass | 3 | 2 | 3 | 86.3 | |||||
waist-hip ratio | 2 | 1 | 2 | 82.9 | |||||
waist circumference | 1 | 1 | 1 | 81.4 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 87.5 | |||||
BMI-adjusted waist circumference | 3 | 86.4 | |||||
appendicular lean mass | 3 | 86.3 | |||||
waist-hip ratio | 2 | 82.9 | |||||
waist circumference | 1 | 81.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ribosomal protein S10 | 718606 | ||||||
Mouse | MGI:1914347 | 67097 | ||||||
Rat | RGD:2323006 | 100363439 | ||||||
Dog | ribosomal protein S10 | 474877 | ||||||
Horse | ribosomal protein S10 | 100062360 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ribosomal protein S10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribosomal protein S10 | |||||
Horse | ribosomal protein S10 | |||||
Publication Statistics
PubMed Score 86.85
PubMed score by year
PubTator Score 104.97
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
|---|