Tbio RPS5 40S ribosomal protein S5

Protein Summary

Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P46782
• B2R4T2
• Q96BN0

Gene Name

• RPS5

Ensembl ID

• ENST00000196551
• ENSP00000196551
• ENSG00000083845
• ENST00000596046
• ENSP00000472985
• ENST00000601521
• ENSP00000470114

Symbol

• S5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	0.95
hub protein	0.94
transcription factor binding site profile	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S5

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.46   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.46   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (578)

Explore Interacting Targets

1 – 10 of 578

• See Interactions on String-DB

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.98166869

p_ni:  0.01833131

Score:  0.428

Data Source:  BioPlex,STRINGDB

RPS2

Tbio

Novelty:  0.00412313

p_int:  0.972703102

p_ni:  0.027296898

Score:  0.999

Data Source:  BioPlex,STRINGDB

THAP3

Tdark

Family:  TF

Novelty:  0.52942342

p_int:  0.928669427

p_ni:  0.071330573

Data Source:  BioPlex

HIST1H1A

Tbio

Novelty:  0.00123818

p_int:  0.893445275

p_ni:  0.106554725

Score:  0.544

Data Source:  BioPlex,STRINGDB

H1FNT

Tdark

Novelty:  0.05593238

p_int:  0.885193089

p_ni:  0.114806911

Data Source:  BioPlex

RPL7A

Tbio

Novelty:  0.01674027

p_int:  0.829907597

p_ni:  0.170092403

Score:  0.999

Data Source:  BioPlex,STRINGDB

NOL12

Tbio

Novelty:  0.15925205

p_int:  0.810247357

p_ni:  0.189752643

Score:  0.589

Data Source:  BioPlex,STRINGDB

ZCRB1

Tbio

Novelty:  0.37592387

p_int:  0.79818559

p_ni:  0.201814409

p_wrong:  1e-9

Score:  0.746

Data Source:  BioPlex,STRINGDB

HIST1H1T

Tdark

Novelty:  0.01039464

p_int:  0.796195949

p_ni:  0.203804051

Score:  0.525

Data Source:  BioPlex,STRINGDB

FGF17

Tbio

Novelty:  0.01432991

p_int:  0.795301766

p_ni:  0.204698234

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (38)

Reactome (36)

KEGG (1)

WikiPathways (1)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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5

1 – 5 of 36

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (4)

Components (7)

Processes (6)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
mRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
rRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	3	3		79.7
platelet count	EFO_0004309	2	2	2		67.4
platelet crit	EFO_0007985	1	1	1		48
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		16.8
puberty onset measurement	EFO_0005677	1	1	1		2.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		79.7
platelet count	EFO_0004309	2		67.4
platelet crit	EFO_0007985	1		48
sex hormone-binding globulin measurement	EFO_0004696	1		16.8
puberty onset measurement	EFO_0005677	1		2.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Isopeptide bond
Phosphoprotein
Reference proteome
Ribonucleoprotein
Ribosomal protein
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume
platelet count
platelet crit
puberty onset measurement
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein S5	VGNC:2261	456347
Macaque	ribosomal protein S5		711259
Mouse	ribosomal protein S5	MGI:1097682	20103
Rat	ribosomal protein S5	RGD:3601	25538
Dog	ribosomal protein S5	VGNC:45737	476366

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein S5
Macaque	ribosomal protein S5
Mouse	ribosomal protein S5
Rat	ribosomal protein S5
Dog	ribosomal protein S5

Publication Statistics

PubMed Score 257.46

PubMed score by year

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PubTator Score 44.16

PubTator score by year

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Related Publications

Text Mined References (31)

GeneRif Annotations (4)

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10

0 of 0

PMID	Year	Title