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Tbio
RPL28
60S ribosomal protein L28

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344063
  • ENSP00000342787
  • ENSG00000108107
  • ENST00000428193
  • ENSP00000391665
  • ENST00000431533
  • ENSP00000400596
  • ENST00000558815
  • ENSP00000452909
  • ENST00000559463
  • ENSP00000453319
  • ENST00000560583
  • ENSP00000453029

Symbol
  • L28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.9
gene perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.27   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.27   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (400)
1 – 10 of 400
HIST1H1D
Tbio
Novelty: 0.01416988
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Data Source: BioPlex
HIST1H1A
Tbio
Novelty: 0.00658293
p_int: 0.999999153
p_ni: 8.47e-7
Data Source: BioPlex
HIST1H1C
Tbio
Novelty: 0.00937936
p_int: 0.9999991
p_ni: 8.99e-7
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03472453
p_int: 0.999992331
p_ni: 0.000007669
Data Source: BioPlex
KLHL21
Tbio
Novelty: 0.51282051
p_int: 0.999970366
p_ni: 0.000029633
Data Source: BioPlex
FAT4
Tbio
Novelty: 0.01665267
p_int: 0.999463804
p_ni: 0.000536196
Data Source: BioPlex
ZDBF2
Tdark
Novelty: 0.17094017
p_int: 0.99864301
p_ni: 0.001356988
p_wrong: 1e-9
Data Source: BioPlex
HASPIN
Tchem
Family: Kinase
Novelty: 0.01885662
p_int: 0.997875551
p_ni: 0.002103056
p_wrong: 0.000021393
Data Source: BioPlex
FAT3
Tbio
Novelty: 0.02603864
p_int: 0.995779586
p_ni: 0.004220414
Data Source: BioPlex
SIPA1L2
Tdark
Novelty: 0.35264082
p_int: 0.99573297
p_ni: 0.004261297
p_wrong: 0.000005733
Data Source: BioPlex
Publication Statistics
PubMed Score  27.27

PubMed score by year
PubTator Score  21.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQ
1-70
RKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS
70-137
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS