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Tbio
RPL5
60S ribosomal protein L5

Protein Summary
Description
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome bioge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370321
  • ENSP00000359345
  • ENSG00000122406
  • ENST00000644759
  • ENSP00000495549

Symbol
  • L5
  • uL18
  • MSTP030
  • PPP1R135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
hub protein
0.98
kinase perturbation
0.96
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.56   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.56   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (571)
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.997804197
p_ni:  0.002195803
Data Source:  BioPlex
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.978499598
p_ni:  0.021500402
Score:  0.252
Data Source:  BioPlex,STRINGDB
ZNF707
Tdark
Family:  TF
Novelty:  1.42194815
p_int:  0.976178122
p_ni:  0.023821878
Data Source:  BioPlex
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.955957915
p_ni:  0.044042085
Score:  0.214
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.92340915
p_ni:  0.07659085
Score:  0.435
Data Source:  BioPlex,STRINGDB
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.881308183
p_ni:  0.118691817
Score:  0.567
Data Source:  BioPlex,STRINGDB
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.865258791
p_ni:  0.134741209
Data Source:  BioPlex
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.855058068
p_ni:  0.144941932
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.852598785
p_ni:  0.147401215
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.850016212
p_ni:  0.149983788
Score:  0.351
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.6
body mass index
1
1
1
50.6
reticulocyte measurement
1
1
1
47.7
body height
1
1
1
46.1
neutrophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.6
body mass index
1
50.6
reticulocyte measurement
1
47.7
body height
1
46.1
neutrophil count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L5
VGNC:1502
457025
Mouse
MGI:102854
100503670
Rat
RGD:619825
81763
Dog
ribosomal protein L5
VGNC:54064
479949
Horse
ribosomal protein L5
VGNC:50877
100033985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L5
Mouse
Rat
Dog
ribosomal protein L5
Horse
ribosomal protein L5
Publication Statistics
PubMed Score 143.56
PubMed score by year
PubTator Score 432.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title