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Tbio
RPL27A
60S ribosomal protein L27a

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314138
  • ENSP00000346015
  • ENSG00000166441

Symbol
  • L27A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor binding site profile
0.87
virus perturbation
0.83
kinase perturbation
0.81
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
11
6
17
94.7
waist-hip ratio
3
2
3
82
2
2
2
80.6
reticulocyte count
1
1
1
75.7
platelet count
1
1
1
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
94.7
waist-hip ratio
3
82
2
80.6
reticulocyte count
1
75.7
platelet count
1
70.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L27a
466438
Macaque
ribosomal protein L27a
708863
Mouse
MGI:1347076
26451
Rat
RGD:1309771
293418
Rat
RGD:1562402
499133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L27a
Macaque
ribosomal protein L27a
Mouse
Rat
Rat
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P46776-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (547)
1 – 10 of 547
EBNA1BP2
Tbio
Novelty:  0.02083466
p_int:  0.767098929
p_ni:  0.232901071
Score:  0.803
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
Score:  0.999
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
RPL6
Tbio
Novelty:  0.01742007
Score:  0.999
Data Source:  STRINGDB
RPL31
Tbio
Novelty:  0.03427872
Score:  0.999
Data Source:  STRINGDB
RPL22
Tbio
Novelty:  0.00473197
Score:  0.999
Data Source:  STRINGDB
RPS12
Tbio
Novelty:  0.00497802
Score:  0.999
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
RPS27L
Tbio
Novelty:  0.17169978
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.65

PubMed score by year
PubTator Score  4.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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