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Tbio
BRCC3
Lys-63-specific deubiquitinase BRCC36

Protein Summary
Description
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330045
  • ENSP00000328641
  • ENSG00000185515
  • ENST00000340647
  • ENSP00000344103
  • ENST00000369459
  • ENSP00000358471
  • ENST00000369462
  • ENSP00000358474

Symbol
  • BRCC36
  • C6.1A
  • CXorf53
  • C6.1A
  • BRCC36
  • CXorf53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.85
interacting protein
0.73
molecular function
0.7
biological process
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.84   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.84   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (233)
BABAM1
Tbio
Novelty:  0.03812501
p_int:  0.999866538
p_ni:  0.000133462
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.997929517
p_ni:  0.002070483
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
UBL4B
Tdark
Novelty:  0.56877836
p_int:  0.995315603
p_ni:  0.004684397
Score:  0.418
Data Source:  BioPlex,STRINGDB
DNAJC25
Tdark
Novelty:  1.55044803
p_int:  0.989528929
p_ni:  0.010471071
Data Source:  BioPlex
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.985511568
p_ni:  0.014488432
Score:  0.828
Data Source:  BioPlex,STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
p_int:  0.955690995
p_ni:  0.044309005
Score:  0.997
Data Source:  BioPlex,STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.854926647
p_ni:  0.145073353
Score:  0.174
Data Source:  BioPlex,STRINGDB
C9orf85
Tdark
Novelty:  4.61061386
p_int:  0.84913077
p_ni:  0.15086923
Data Source:  BioPlex
UIMC1
Tbio
Novelty:  0.02039732
Score:  0.999
Data Source:  STRINGDB
BABAM2
Tbio
Novelty:  0.00448485
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
57.7
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BRCA1/BRCA2-containing complex subunit 3
702888
Mouse
MGI:2389572
210766
Rat
RGD:1588543
316794
Horse
BRCA1/BRCA2-containing complex subunit 3
VGNC:15880
100062237
Cow
BRCA1/BRCA2-containing complex subunit 3
VGNC:26555
519513
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BRCA1/BRCA2-containing complex subunit 3
Mouse
Rat
Horse
BRCA1/BRCA2-containing complex subunit 3
Cow
BRCA1/BRCA2-containing complex subunit 3
Publication Statistics
PubMed Score 20.84
PubMed score by year
PubTator Score 26.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title