MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3
Protein Summary
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Y ...more
- ENST00000316920
- ENSP00000319139
- ENSG00000034152
- ENST00000342679
- ENSP00000345083
- ENST00000361818
- ENSP00000355081
- ENST00000613338
- ENSP00000478619
- MEK3
- MKK3
- PRKMK3
- SKK2
- MEK3
- MKK3
- MAPKK3
- PRKMK3
- SAPKK2
- SAPKK-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.99 | ||
biological process | 0.92 | ||
pathway | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.8 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 1253 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.8 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 1253 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (131)
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.99999906
p_ni: 9.4e-7
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
LY86
Novelty: 0.00314575
p_int: 0.977249158
p_ni: 0.002083312
p_wrong: 0.020667529
Data Source: BioPlex
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (131)
Reactome (31)
KEGG (16)
PathwayCommons (38)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (5)
Components (4)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 4 | 93.6 | |||||
body mass index | 6 | 3 | 6 | 88.3 | |||||
body height | 3 | 3 | 3 | 83.8 | |||||
reticulocyte count | 2 | 3 | 3 | 82.8 | |||||
waist-hip ratio | 3 | 2 | 3 | 75.7 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 4 | 93.6 | |||||
body mass index | 6 | 88.3 | |||||
body height | 3 | 83.8 | |||||
reticulocyte count | 3 | 82.8 | |||||
waist-hip ratio | 3 | 75.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase 3 | 705195 | ||||||
Mouse | MGI:1346868 | 26397 | ||||||
Rat | RGD:1306620 | 303200 | ||||||
Dog | mitogen-activated protein kinase kinase 3 | VGNC:42961 | 489547 | |||||
Cow | mitogen-activated protein kinase kinase 3 | VGNC:31184 | 516039 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase 3 | |||||
Cow | mitogen-activated protein kinase kinase 3 | |||||
Publication Statistics
PubMed Score 249.80
PubMed score by year
PubTator Score 133.42
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (73)
GeneRif Annotations (36)
Items per page:
0 of 0
PMID | Year | Title |
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