MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3
Protein Summary
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Y ...more
- ENST00000316920
- ENSP00000319139
- ENSG00000034152
- ENST00000342679
- ENSP00000345083
- ENST00000361818
- ENSP00000355081
- ENST00000613338
- ENSP00000478619
- MEK3
- MKK3
- PRKMK3
- SKK2
- MEK3
- MKK3
- MAPKK3
- PRKMK3
- SAPKK2
- SAPKK-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.99 | ||
biological process | 0.92 | ||
pathway | 0.91 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.78 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 1253 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.78 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 1253 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
Pathways (131)
Reactome (31)
KEGG (16)
PathwayCommons (38)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 31
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Gene Ontology Terms (22)
Functions (5)
Components (4)
Processes (13)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (131)
1 – 10 of 131
MAP2K6
Family: Kinase
Novelty: 0.00880457
p_int: 1
Score: 0.97
Data Source: BioPlex,STRINGDB
MAPK14
Family: Kinase
Novelty: 0.00018655
p_int: 0.99999906
p_ni: 9.4e-7
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
CD70
Novelty: 0.00552433
p_int: 0.999385125
p_ni: 0.000614874
p_wrong: 1e-9
Data Source: BioPlex
LY86
Novelty: 0.00136228
p_int: 0.977249158
p_ni: 0.002083312
p_wrong: 0.020667529
Data Source: BioPlex
MAPK11
Family: Kinase
Novelty: 0.00860226
Score: 0.983
Data Source: Reactome,STRINGDB
TAOK2
Family: Kinase
Novelty: 0.02828827
Score: 0.977
Data Source: STRINGDB
MAPK12
Family: Kinase
Novelty: 0.01020422
Score: 0.975
Data Source: STRINGDB
TAB1
Family: Kinase
Novelty: 0.01006931
Score: 0.965
Data Source: STRINGDB
MAPK13
Family: Kinase
Novelty: 0.00235189
Score: 0.965
Data Source: STRINGDB
MAP3K5
Family: Kinase
Novelty: 0.00192027
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 196.78
PubMed score by year
PubTator Score 133.42
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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UniProt Keyword
GWAS Trait