You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3

Protein Summary
Description
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Y ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316920
  • ENSP00000319139
  • ENSG00000034152
  • ENST00000342679
  • ENSP00000345083
  • ENST00000361818
  • ENSP00000355081
  • ENST00000613338
  • ENSP00000478619

Symbol
  • MEK3
  • MKK3
  • PRKMK3
  • SKK2
  • MEK3
  • MKK3
  • MAPKK3
  • PRKMK3
  • SAPKK2
  • SAPKK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
molecular function
0.99
biological process
0.92
pathway
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 1253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 1253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0