MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.99 | ||
biological process | 0.92 | ||
pathway | 0.91 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 4 | 93.6 | |||||
body mass index | 6 | 3 | 6 | 88.3 | |||||
body height | 3 | 3 | 3 | 83.8 | |||||
reticulocyte count | 2 | 3 | 3 | 82.8 | |||||
waist-hip ratio | 3 | 2 | 3 | 75.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 4 | 93.6 | |||||
body mass index | 6 | 88.3 | |||||
body height | 3 | 83.8 | |||||
reticulocyte count | 3 | 82.8 | |||||
waist-hip ratio | 3 | 75.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase 3 | 705195 | ||||||
Mouse | MGI:1346868 | 26397 | ||||||
Rat | RGD:1306620 | 303200 | ||||||
Dog | mitogen-activated protein kinase kinase 3 | VGNC:42961 | 489547 | |||||
Cow | mitogen-activated protein kinase kinase 3 | VGNC:31184 | 516039 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase 3 | |||||
Cow | mitogen-activated protein kinase kinase 3 | |||||
PMID | Year | Title |
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