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Tchem
MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3

Protein Summary
Description
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Y ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316920
  • ENSP00000319139
  • ENSG00000034152
  • ENST00000342679
  • ENSP00000345083
  • ENST00000361818
  • ENSP00000355081
  • ENST00000613338
  • ENSP00000478619

Symbol
  • MEK3
  • MKK3
  • PRKMK3
  • SKK2
  • MEK3
  • MKK3
  • MAPKK3
  • PRKMK3
  • SAPKK2
  • SAPKK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
molecular function
0.99
biological process
0.92
pathway
0.91


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.31   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 1253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.31   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 1253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
3
6
98.2
waist-hip ratio
2
1
2
50.4
mean corpuscular hemoglobin concentration
1
1
1
24.3
body height
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
98.2
waist-hip ratio
2
50.4
mean corpuscular hemoglobin concentration
1
24.3
body height
1
6.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase 3
705195
Mouse
MGI:1346868
26397
Rat
RGD:1306620
303200
Dog
mitogen-activated protein kinase kinase 3
VGNC:42961
489547
Cow
mitogen-activated protein kinase kinase 3
VGNC:31184
516039
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase 3
Mouse
Rat
Dog
mitogen-activated protein kinase kinase 3
Cow
mitogen-activated protein kinase kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P46734-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (131)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (131)
1 – 10 of 131
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
p_int: 1
Score: 0.97
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.99999906
p_ni: 9.4e-7
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999385125
p_ni: 0.000614874
p_wrong: 1e-9
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.977249158
p_ni: 0.002083312
p_wrong: 0.020667529
Data Source: BioPlex
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.983
Data Source: Reactome,STRINGDB
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
Score: 0.977
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.975
Data Source: STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
Score: 0.965
Data Source: STRINGDB
MAPK13
Tchem
Family: Kinase
Novelty: 0.01071621
Score: 0.965
Data Source: STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00144614
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  242.31

PubMed score by year
PubTator Score  133.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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