SLCO1A2
Solute carrier organic anion transporter family member 1A2
Protein Summary
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- ENST00000307378
- ENSP00000305974
- ENSG00000084453
- OATP
- OATP1
- OATP1A2
- SLC21A3
- OATP
- OATP-A
- OATP1A2
- SLC21A3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
gene perturbation | 0.8 | ||
cell type or tissue | 0.71 | ||
microRNA | 0.6 | ||
cell line | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 412.05 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 412.05 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0