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Tchem
SLCO1A2
Solute carrier organic anion transporter family member 1A2

Protein Summary
Description
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307378
  • ENSP00000305974
  • ENSG00000084453

Symbol
  • OATP
  • OATP1
  • OATP1A2
  • SLC21A3
  • OATP
  • OATP-A
  • OATP1A2
  • SLC21A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.8
cell type or tissue
0.71
microRNA
0.6
cell line
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.2   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.2   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (109)
ALB
Tchem
Novelty:  0.00000616
Score:  0.936
Data Source:  Reactome,STRINGDB
ACOT11
Tbio
Family:  Enzyme
Novelty:  0.0400726
Score:  0.893
Data Source:  STRINGDB
LIX1
Tbio
Novelty:  0.03028158
Score:  0.849
Data Source:  STRINGDB
RUBCNL
Tbio
Novelty:  0.20019585
Score:  0.841
Data Source:  STRINGDB
PGM2
Tbio
Family:  Enzyme
Novelty:  0.00922421
Score:  0.841
Data Source:  STRINGDB
C1orf109
Tdark
Novelty:  0.93042195
Score:  0.841
Data Source:  STRINGDB
SHD
Tbio
Novelty:  0.05144274
Score:  0.841
Data Source:  STRINGDB
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
Score:  0.841
Data Source:  STRINGDB
CWC25
Tdark
Novelty:  0.13727856
Score:  0.841
Data Source:  STRINGDB
CD300LG
Tbio
Novelty:  0.12664188
Score:  0.839
Data Source:  STRINGDB
Pathways (10)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Recycling of bile acids and salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Recycling of bile acids and salts
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
4
18
30
99.9
blood metabolite measurement
2
4
14
98.8
sex hormone-binding globulin measurement
7
3
7
97.8
serum metabolite measurement
1
3
10
97.2
testosterone measurement
4
2
4
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
30
99.9
blood metabolite measurement
14
98.8
sex hormone-binding globulin measurement
7
97.8
serum metabolite measurement
10
97.2
testosterone measurement
4
91.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 1A2
VGNC:8550
473385
Macaque
solute carrier organic anion transporter family member 1A2
705434
Mouse
MGI:1351896
28250
Dog
solute carrier organic anion transporter family member 1A2
VGNC:46493
403520
Horse
solute carrier organic anion transporter family member 1A2
VGNC:23287
100034162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 1A2
Macaque
solute carrier organic anion transporter family member 1A2
Mouse
Dog
solute carrier organic anion transporter family member 1A2
Horse
solute carrier organic anion transporter family member 1A2
Publication Statistics
PubMed Score 376.20
PubMed score by year
PubTator Score 279.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title